GenAge entry for PCK1 (Homo sapiens)
Gene name (HAGRID: 248)
- HGNC symbol
- PCK1
- Aliases
- PEPCK-C
- Common name
- phosphoenolpyruvate carboxykinase 1 (soluble)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
PCK1 is involved in the regulation of gluconeogenesis. Mice with PCK1 overexpressed in skeletal muscle were more active than controls and had an enhanced exercise capacity with an increased number of mitochondria. These mice ate more than controls, but had half the body weight and 10% the body fat. They were also reported to be long-lived [1839], though detailed ageing studies have not been conducted yet.
Cytogenetic information
- Cytogenetic band
- 20q13.31
- Location
- 57,561,081 bp to 57,566,457 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006006; glucose metabolic process
GO:0006094; gluconeogenesis
GO:0006107; oxaloacetate metabolic process
GO:0006475; internal protein amino acid acetylation
GO:0007568; aging
GO:0014823; response to activity
GO:0032496; response to lipopolysaccharide
GO:0032868; response to insulin
GO:0032869; cellular response to insulin stimulus
GO:0042593; glucose homeostasis
GO:0046327; glycerol biosynthetic process from pyruvate
And 12 more GO terms Cellular component: GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0070062; extracellular exosome
Function: GO:0000287; magnesium ion binding
GO:0004613; phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525; GTP binding
GO:0019003; GDP binding
GO:0030145; manganese ion binding
GO:0031406; carboxylic acid binding
Protein interactions and network
Retrieve sequences for PCK1
Homologs in model organisms
- Caenorhabditis elegans
- pck-3
- Caenorhabditis elegans
- pck-1
- Caenorhabditis elegans
- pck-2
- Danio rerio
- pck1
- Drosophila melanogaster
- CG10924
- Drosophila melanogaster
- Pepck
- Mus musculus
- Pck1
- Rattus norvegicus
- Pck1
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Mus musculus is present as Pck1
Selected references
External links
- EPD
- ORF Accession
- NM_002591
- CDS Accession
- NP_002582
- OMIM
- 261680
- HPRD
- 02028
- Ensembl
- PCK1
- UniProt/Swiss-Prot
- PCKGC_HUMAN
- GeneCards
- PCK1
- Entrez Gene
- 5105
- GenAtlas
- PCK1
- Internet
- Search Google