GenAge entry for PCK1 (Homo sapiens)

Gene name (HAGRID: 248)

HGNC symbol
PCK1 
Aliases
PEPCK-C 
Common name
phosphoenolpyruvate carboxykinase 1 (soluble) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

PCK1 is involved in the regulation of gluconeogenesis. Mice with PCK1 overexpressed in skeletal muscle were more active than controls and had an enhanced exercise capacity with an increased number of mitochondria. These mice ate more than controls, but had half the body weight and 10% the body fat. They were also reported to be long-lived [1839], though detailed ageing studies have not been conducted yet.

Cytogenetic information

Cytogenetic band
20q13.31
Location
57,561,081 bp to 57,566,457 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006006; glucose metabolic process
GO:0006094; gluconeogenesis
GO:0006107; oxaloacetate metabolic process
GO:0006475; internal protein amino acid acetylation
GO:0007568; aging
GO:0014823; response to activity
GO:0032496; response to lipopolysaccharide
GO:0032868; response to insulin
GO:0032869; cellular response to insulin stimulus
GO:0042593; glucose homeostasis
GO:0046327; glycerol biosynthetic process from pyruvate
And 12 more GO terms
Cellular component: GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0070062; extracellular exosome
Function: GO:0000287; magnesium ion binding
GO:0004613; phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525; GTP binding
GO:0019003; GDP binding
GO:0030145; manganese ion binding
GO:0031406; carboxylic acid binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EP300, APP, HSPD1, SQSTM1
STRING interaction network
Protein-Protein network diagram for PCK1

Retrieve sequences for PCK1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
pck-3
Caenorhabditis elegans
pck-1
Caenorhabditis elegans
pck-2
Danio rerio
pck1
Drosophila melanogaster
CG10924
Drosophila melanogaster
Pepck
Mus musculus
Pck1
Rattus norvegicus
Pck1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Pck1
  • A homolog of this gene for Caenorhabditis elegans is present as pck-2
GenDR gene manipulations
  • A homolog of this gene for Mus musculus is present as Pck1

Selected references

External links

EPD
ORF Accession
NM_002591
CDS Accession
NP_002582
OMIM
261680
HPRD
02028
Ensembl
PCK1
UniProt/Swiss-Prot
PCKGC_HUMAN
GeneCards
PCK1
Entrez Gene
5105
UniGene
1872
GenAtlas
PCK1
Internet
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