GenAge entry for PIK3R1 (Homo sapiens)
Gene name (HAGRID: 185)
- HGNC symbol
- PIK3R1
- Aliases
- GRB1; p85-ALPHA; p85
- Common name
- phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Together with PIK3CB, PIK3R1 is involved in insulin (INS) signalling and energy metabolism [806]. Disruption of PIK3CB in mice results in death shortly after birth and impaired B cell development [804]. Although PIK3CB has not been directly related to human ageing, PIK3CB may be associated with signalling pathways that impact on human ageing.
Cytogenetic information
- Cytogenetic band
- 5q13.1
- Location
- 68,215,756 bp to 68,301,821 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001678; cellular glucose homeostasis
GO:0001953; negative regulation of cell-matrix adhesion
GO:0006468; protein phosphorylation
GO:0006661; phosphatidylinositol biosynthetic process
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0008286; insulin receptor signaling pathway
GO:0008625; extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0014065; phosphatidylinositol 3-kinase signaling
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0016032; viral process
And 34 more GO terms Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005801; cis-Golgi network
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0005942; phosphatidylinositol 3-kinase complex
GO:0005943; phosphatidylinositol 3-kinase complex, class IA
GO:0016020; membrane
GO:0043234; protein complex
GO:1990578; perinuclear endoplasmic reticulum membrane
And 1 more GO terms Function: GO:0005068; transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158; insulin receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005168; neurotrophin TRKA receptor binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0019903; protein phosphatase binding
GO:0035014; phosphatidylinositol 3-kinase regulator activity
GO:0036312; phosphatidylinositol 3-kinase regulatory subunit binding
GO:0043125; ErbB-3 class receptor binding
And 7 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, IGF1R, PTPN11, STAT3, HDAC3, IRS1, IRS2, PIK3CB, HRAS, EGFR, ERBB2, PDGFRB, EPOR, PLCG2, BRCA1, ABL1, EP300, HTT, GRB2, SIRT1, PTK2, FGFR1, FLT1, MAP3K5, PIK3R1, JAK2, ESR1, NFKBIA, CTNNB1, ARHGAP1, PDGFRA, PIK3CA, SQSTM1
- STRING interaction network
Retrieve sequences for PIK3R1
Homologs in model organisms
- Caenorhabditis elegans
- aap-1
- Danio rerio
- pik3r1
- Drosophila melanogaster
- Pi3K21B
- Mus musculus
- Pik3r1
- Rattus norvegicus
- Pik3r1
In other databases
- LongevityMap
- This gene is present as PIK3R1
Selected references
External links
- EPD
- ORF Accession
- NM_181523
- CDS Accession
- NP_852664
- OMIM
- 171833
- HPRD
- 01381
- Ensembl
- PIK3R1
- UniProt/Swiss-Prot
- P85A_HUMAN
- GeneCards
- PIK3R1
- Entrez Gene
- 5295
- GenAtlas
- PIK3R1
- Internet
- Search Google