GenAge entry for PIK3R1 (Homo sapiens)

Gene name (HAGRID: 185)

HGNC symbol
PIK3R1 
Aliases
GRB1; p85-ALPHA; p85 
Common name
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Together with PIK3CB, PIK3R1 is involved in insulin (INS) signalling and energy metabolism [806]. Disruption of PIK3CB in mice results in death shortly after birth and impaired B cell development [804]. Although PIK3CB has not been directly related to human ageing, PIK3CB may be associated with signalling pathways that impact on human ageing.

Cytogenetic information

Cytogenetic band
5q13.1
Location
68,215,756 bp to 68,301,821 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001678; cellular glucose homeostasis
GO:0001953; negative regulation of cell-matrix adhesion
GO:0006468; protein phosphorylation
GO:0006661; phosphatidylinositol biosynthetic process
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0008286; insulin receptor signaling pathway
GO:0008625; extrinsic apoptotic signaling pathway via death domain receptors
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0014065; phosphatidylinositol 3-kinase signaling
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0016032; viral process
And 34 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005801; cis-Golgi network
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0005942; phosphatidylinositol 3-kinase complex
GO:0005943; phosphatidylinositol 3-kinase complex, class IA
GO:0016020; membrane
GO:0043234; protein complex
GO:1990578; perinuclear endoplasmic reticulum membrane
And 1 more GO terms
Function: GO:0005068; transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158; insulin receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005168; neurotrophin TRKA receptor binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0019903; protein phosphatase binding
GO:0035014; phosphatidylinositol 3-kinase regulator activity
GO:0036312; phosphatidylinositol 3-kinase regulatory subunit binding
GO:0043125; ErbB-3 class receptor binding
And 7 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, IGF1R, PTPN11, STAT3, IRS1, IRS2, PIK3CB, HRAS, EGFR, ERBB2, PDGFRB, EPOR, PLCG2, HDAC3, BRCA1, ABL1, EP300, HTT, GRB2, SIRT1, PTK2, FGFR1, FLT1, MAP3K5, PIK3R1, JAK2, ESR1, NFKBIA, CTNNB1, ARHGAP1, PDGFRA, PIK3CA, SQSTM1
STRING interaction network
Protein-Protein network diagram for PIK3R1

Retrieve sequences for PIK3R1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
aap-1
Danio rerio
pik3r1
Drosophila melanogaster
Pi3K21B
Mus musculus
Pik3r1
Rattus norvegicus
Pik3r1

In other databases

LongevityMap
  • This gene is present as PIK3R1

Selected references

External links

EPD
ORF Accession
NM_181523
CDS Accession
NP_852664
OMIM
171833
HPRD
01381
Ensembl
PIK3R1
UniProt/Swiss-Prot
P85A_HUMAN
GeneCards
PIK3R1
Entrez Gene
5295
UniGene
132225
GenAtlas
PIK3R1
Internet
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