GenAge entry for NCOR2 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 276)
- HGNC symbol
- NCOR2
- Aliases
- SMRT; SMRTE; TRAC-1; CTG26; TNRC14
- Common name
- nuclear receptor corepressor 2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
NCOR2, also known as SMRT, is a transcriptional corepressor that maintains the transcriptional silencing of certain target genes. NCOR2 expression and its occupancy on peroxisome proliferator-activated receptor (PPAR) target gene promoters are increased with age in major metabolic tissues. Shifting its repressive activity towards PPARs, by selectively disabling one of its two major receptor-interacting domains, resulted in premature ageing in mice and related metabolic diseases accompanied by reduced mitochondrial function and antioxidant gene expression. Additionally, in a preliminary analysis, several human polymorphisms were found to be associated with type 2 diabetes [2196].
Cytogenetic information
- Cytogenetic band
- 12q24
- Location
- 124,324,411 bp to 124,567,464 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0044255; cellular lipid metabolic process
GO:0072365; regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter
GO:1903799; negative regulation of production of miRNAs involved in gene silencing by miRNA
Cellular component: GO:0000118; histone deacetylase complex
GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0016020; membrane
GO:0016363; nuclear matrix
GO:0016604; nuclear body
GO:0017053; transcriptional repressor complex
Function: GO:0003677; DNA binding
GO:0003714; transcription corepressor activity
GO:0005112; Notch binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016922; ligand-dependent nuclear receptor binding
GO:0042826; histone deacetylase binding
GO:0047485; protein N-terminus binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- E2F1, HDAC3, AKT1, NCOR1, FOS, PPARA, CREBBP, NR3C1, NFKB1, UBE2I, CEBPB, EP300, PML, AR, RELA, HDAC1, SP1, JUN, SIN3A, HDAC2, SUMO1, ESR1, NFKBIA, PPARG, NFE2L2, CDKN1A
- STRING interaction network
Retrieve sequences for NCOR2
Homologs in model organisms
- Caenorhabditis elegans
- gei-8
- Danio rerio
- ncor2
- Drosophila melanogaster
- Smr
- Mus musculus
- Ncor2
- Rattus norvegicus
- Ncor2
- Saccharomyces cerevisiae
- SNT1
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Ncor2
Selected references
External links
- EPD
- ORF Accession
- NM_001206654
- CDS Accession
- NP_001193583
- OMIM
- 600848
- HPRD
- 02910
- Ensembl
- NCOR2
- UniProt/Swiss-Prot
- NCOR2_HUMAN
- GeneCards
- NCOR2
- Entrez Gene
- 9612
- GenAtlas
- NCOR2
- Internet
- Search Google