GenAge entry for RGN (Homo sapiens)

Gene name (HAGRID: 145)

HGNC symbol
RGN 
Aliases
SMP30; RC 
Common name
regucalcin 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

RGN is mostly expressed in the liver, yet its functions remain obscure [723]. Its expression levels decline with age, and RGN has been linked to age-related changes in calcium signalling in the liver of rats [724]. RGN-null mice show susceptibility to TNF- and FAS-mediated apoptosis [182] and increased oxidative stress in brain [1634]. SMP30/SOD1-double knockout mice exhibit abnormal plasma lipid metabolism, hepatic lipid accumulation and premature death resulting from impaired VLDL secretion, both compared to wild type, SMP30-knockout and SOD1-knockout mice [3618]. A role for RGN in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
Xp11.3
Location
47,078,355 bp to 47,093,314 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001822; kidney development
GO:0006469; negative regulation of protein kinase activity
GO:0006874; cellular calcium ion homeostasis
GO:0007283; spermatogenesis
GO:0007568; aging
GO:0010867; positive regulation of triglyceride biosynthetic process
GO:0010907; positive regulation of glucose metabolic process
GO:0010922; positive regulation of phosphatase activity
GO:0019853; L-ascorbic acid biosynthetic process
GO:0032515; negative regulation of phosphoprotein phosphatase activity
GO:0032781; positive regulation of ATPase activity
And 21 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0004341; gluconolactonase activity
GO:0005509; calcium ion binding
GO:0008270; zinc ion binding
GO:0030234; enzyme regulator activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SOD1
STRING interaction network
Protein-Protein network diagram for RGN

Retrieve sequences for RGN

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
rgn
Drosophila melanogaster
smp-30
Drosophila melanogaster
regucalcin
Mus musculus
Rgn
Rattus norvegicus
Rgn

Selected references

External links

EPD
ORF Accession
NM_004683
CDS Accession
NP_004674
OMIM
300212
HPRD
02196
Ensembl
RGN
UniProt/Swiss-Prot
RGN_HUMAN
GeneCards
RGN
Entrez Gene
9104
UniGene
77854
GenAtlas
RGN
Internet
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