GenAge entry for SIN3A (Homo sapiens)
Gene name (HAGRID: 200)
- HGNC symbol
- SIN3A
- Aliases
- KIAA0700; DKFZP434K2235
- Common name
- SIN3 transcription regulator family member A
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
SIN3A is a transcriptional regulator that interacts with MXI1 to antagonize MYC [982]. Neuronal apoptosis has been related to elevated SIN3A levels [1735], though SIN3A expression levels did not increase with age in rats [873]. SIN3A has not been directly related to human ageing.
Cytogenetic information
- Cytogenetic band
- 15q24.2
- Location
- 75,369,379 bp to 75,451,585 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001701; in utero embryonic development
GO:0002218; activation of innate immune response
GO:0002230; positive regulation of defense response to virus by host
GO:0002244; hematopoietic progenitor cell differentiation
GO:0006260; DNA replication
GO:0006351; transcription, DNA-templated
GO:0006476; protein deacetylation
GO:0007568; aging
GO:0010817; regulation of hormone levels
GO:0010971; positive regulation of G2/M transition of mitotic cell cycle
And 17 more GO terms Cellular component: GO:0000776; kinetochore
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0016580; Sin3 complex
GO:0017053; transcriptional repressor complex
GO:0045171; intercellular bridge
Function: GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0001106; RNA polymerase II transcription corepressor activity
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003723; RNA binding
GO:0004407; histone deacetylase activity
GO:0005515; protein binding
GO:0032403; protein complex binding
GO:0033558; protein deacetylase activity
And 1 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, STAT3, NCOR1, HIF1A, HSP90AA1, PML, AR, HDAC1, SP1, TAF1, TBP, HBP1, HDAC2, MAX, MXD1, ESR1, NCOR2
- STRING interaction network
Retrieve sequences for SIN3A
Homologs in model organisms
- Caenorhabditis elegans
- sin-3
- Danio rerio
- sin3aa
- Danio rerio
- sin3ab
- Drosophila melanogaster
- Sin3A
- Mus musculus
- Sin3a
- Rattus norvegicus
- Sin3a
- Saccharomyces cerevisiae
- SIN3
Selected references
External links
- EPD
- ORF Accession
- NM_015477
- CDS Accession
- NP_056292
- OMIM
- 607776
- HPRD
- 09690
- Ensembl
- SIN3A
- UniProt/Swiss-Prot
- SIN3A_HUMAN
- GeneCards
- SIN3A
- Entrez Gene
- 25942
- GenAtlas
- SIN3A
- Internet
- Search Google