GenAge entry for SIN3A (Homo sapiens)

Gene name (HAGRID: 200)

HGNC symbol
SIN3A 
Aliases
KIAA0700; DKFZP434K2235 
Common name
SIN3 transcription regulator family member A 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

SIN3A is a transcriptional regulator that interacts with MXI1 to antagonize MYC [982]. Neuronal apoptosis has been related to elevated SIN3A levels [1735], though SIN3A expression levels did not increase with age in rats [873]. SIN3A has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band
15q24.2
Location
75,369,379 bp to 75,451,585 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001701; in utero embryonic development
GO:0002218; activation of innate immune response
GO:0002230; positive regulation of defense response to virus by host
GO:0002244; hematopoietic progenitor cell differentiation
GO:0006260; DNA replication
GO:0006351; transcription, DNA-templated
GO:0006476; protein deacetylation
GO:0007568; aging
GO:0010817; regulation of hormone levels
GO:0010971; positive regulation of G2/M transition of mitotic cell cycle
And 17 more GO terms
Cellular component: GO:0000776; kinetochore
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0016580; Sin3 complex
GO:0017053; transcriptional repressor complex
GO:0045171; intercellular bridge
Function: GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0001106; RNA polymerase II transcription corepressor activity
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003723; RNA binding
GO:0004407; histone deacetylase activity
GO:0005515; protein binding
GO:0032403; protein complex binding
GO:0033558; protein deacetylase activity
And 1 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, STAT3, NCOR1, HIF1A, HSP90AA1, PML, AR, HDAC1, SP1, TAF1, TBP, HBP1, HDAC2, MAX, MXD1, ESR1, NCOR2
STRING interaction network
Protein-Protein network diagram for SIN3A

Retrieve sequences for SIN3A

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
sin-3
Danio rerio
sin3aa
Danio rerio
sin3ab
Drosophila melanogaster
Sin3A
Mus musculus
Sin3a
Rattus norvegicus
Sin3a
Saccharomyces cerevisiae
SIN3

Selected references

External links

EPD
ORF Accession
NM_015477
CDS Accession
NP_056292
OMIM
607776
HPRD
09690
Ensembl
SIN3A
UniProt/Swiss-Prot
SIN3A_HUMAN
GeneCards
SIN3A
Entrez Gene
25942
UniGene
513039
GenAtlas
SIN3A
Internet
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