GenAge entry for TRPV1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 306)

HGNC symbol
TRPV1 
Aliases
VR1 
Common name
transient receptor potential cation channel subfamily V member 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]

Cytogenetic information

Cytogenetic band
17p13.2
Location
3,565,445 bp to 3,609,410 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001660; fever generation
GO:0001774; microglial cell activation
GO:0002024; diet induced thermogenesis
GO:0002790; peptide secretion
GO:0006629; lipid metabolic process
GO:0006810; transport
GO:0007166; cell surface receptor signaling pathway
GO:0007635; chemosensory behavior
GO:0014047; glutamate secretion
GO:0034605; cellular response to heat
And 24 more GO terms
Cellular component: GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009897; external side of plasma membrane
GO:0016021; integral component of membrane
GO:0030054; cell junction
GO:0030425; dendrite
GO:0031226; intrinsic component of plasma membrane
GO:0032591; dendritic spine membrane
GO:0043025; neuronal cell body
GO:0045211; postsynaptic membrane
And 1 more GO terms
Function: GO:0004888; transmembrane signaling receptor activity
GO:0005230; extracellular ligand-gated ion channel activity
GO:0005231; excitatory extracellular ligand-gated ion channel activity
GO:0005262; calcium channel activity
GO:0005516; calmodulin binding
GO:0005524; ATP binding
GO:0015278; calcium-release channel activity
GO:0017081; chloride channel regulator activity
GO:0035091; phosphatidylinositol binding
GO:0042802; identical protein binding
GO:0046872; metal ion binding
And 3 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EGFR, TRPV1
STRING interaction network
Protein-Protein network diagram for TRPV1

Retrieve sequences for TRPV1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
ocr-2
Caenorhabditis elegans
ocr-3
Caenorhabditis elegans
ocr-1
Caenorhabditis elegans
ocr-4
Caenorhabditis elegans
osm-9
Danio rerio
trpv1
Drosophila melanogaster
nan
Drosophila melanogaster
iav
Mus musculus
Trpv1
Rattus norvegicus
Trpv1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as ocr-2
  • A homolog of this gene for Mus musculus is present as Trpv1

Selected references

External links

EPD
ORF Accession
NM_018727
CDS Accession
NP_061197
OMIM
602076
HPRD
Ensembl
TRPV1
UniProt/Swiss-Prot
TRPV1_HUMAN
GeneCards
TRPV1
Entrez Gene
7442
UniGene
579217
GenAtlas
TRPV1
Internet
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