GenAge entry for TFAP2A (Homo sapiens)

Gene name (HAGRID: 190)

HGNC symbol
TFAP2A 
Aliases
AP-2; TFAP2; AP2TF 
Common name
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

TFAP2A is a transcription factor involved in a variety of processes, including development and morphogenesis. Disruption of TFAP2A results in multiple developmental defects and death at birth [821]. Due to its association with WRN and other helicases [819], it is possible, though unproven, that TFAP2A plays some role in human ageing.

Cytogenetic information

Cytogenetic band
6p24
Location
10,396,683 bp to 10,415,237 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001822; kidney development
GO:0003404; optic vesicle morphogenesis
GO:0003409; optic cup structural organization
GO:0006366; transcription from RNA polymerase II promoter
GO:0007605; sensory perception of sound
GO:0008285; negative regulation of cell proliferation
GO:0010628; positive regulation of gene expression
GO:0010842; retina layer formation
GO:0010944; negative regulation of transcription by competitive promoter binding
GO:0021559; trigeminal nerve development
And 18 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005794; Golgi apparatus
GO:0005813; centrosome
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0000982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987; core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, MYC, BRCA1, NFKB1, UBE2I, EP300, XRCC5, XRCC6, RB1, RELA, SP1, JUN, MAX, CTNNB1, PPARG
STRING interaction network
Protein-Protein network diagram for TFAP2A

Retrieve sequences for TFAP2A

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
aptf-1
Danio rerio
tfap2a
Drosophila melanogaster
TfAP-2
Mus musculus
Tfap2a
Rattus norvegicus
Tfap2a

Selected references

External links

EPD
ORF Accession
NM_003220
CDS Accession
NP_003211
OMIM
107580
HPRD
00128
Ensembl
TFAP2A
UniProt/Swiss-Prot
AP2A_HUMAN
GeneCards
TFAP2A
Entrez Gene
7020
UniGene
519880
GenAtlas
TFAP2A
Internet
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