GenAge entry for HSPA8 (Homo sapiens)

Gene name (HAGRID: 199)

HGNC symbol
HSPA8 
Aliases
HSC71; HSC70; HSP73; HSPA10 
Common name
heat shock 70kDa protein 8 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Also called hsc70 and hsp73, HSPA8 is a constitutively expressed chaperone. Age-related changes in stress response have been reported in rats, though HSPA8 levels do not appear to change with age [915]. Whether HSPA8 plays any role in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band
11q24.1
Location
123,057,492 bp to 123,062,335 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000398; mRNA splicing, via spliceosome
GO:0006351; transcription, DNA-templated
GO:0006457; protein folding
GO:0006986; response to unfolded protein
GO:0007269; neurotransmitter secretion
GO:0009267; cellular response to starvation
GO:0016032; viral process
GO:0031647; regulation of protein stability
GO:0042026; protein refolding
GO:0043254; regulation of protein complex assembly
GO:0043488; regulation of mRNA stability
And 18 more GO terms
Cellular component: GO:0000151; ubiquitin ligase complex
GO:0000974; Prp19 complex
GO:0005615; extracellular space
GO:0005622; intracellular
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005681; spliceosomal complex
GO:0005730; nucleolus
GO:0005765; lysosomal membrane
GO:0005770; late endosome
GO:0005829; cytosol
And 15 more GO terms
Function: GO:0001664; G-protein coupled receptor binding
GO:0001786; phosphatidylserine binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016887; ATPase activity
GO:0019899; enzyme binding
GO:0023026; MHC class II protein complex binding
GO:0031072; heat shock protein binding
GO:0031625; ubiquitin protein ligase binding
GO:0042623; ATPase activity, coupled
GO:0044822; poly(A) RNA binding
And 4 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, ATM, AKT1, EGFR, HDAC3, BRCA1, PTEN, HIF1A, RPA1, HSP90AA1, ABL1, HTT, EEF2, PRKDC, GRB2, HSF1, SOD1, UCHL1, APP, RAD52, HSPD1, HSPA1A, MAPK8, JUN, HMGB1, LMNB1, EEF1A1, JAK2, HSPA9, MDM2, RELA, VCP, ESR1, CTNNB1, CDKN2A, PPP1CA, MAPT, SIRT6, STUB1, CDKN1A, SPRTN
STRING interaction network
Protein-Protein network diagram for HSPA8

Retrieve sequences for HSPA8

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
hsp-1
Danio rerio
HSPA8 (1 of many)
Danio rerio
hspa8
Drosophila melanogaster
Hsc70-1
Drosophila melanogaster
Hsc70-4
Mus musculus
Hspa8
Rattus norvegicus
LOC680121
Rattus norvegicus
Hspa8
Rattus norvegicus
Hspa8
Rattus norvegicus
AABR07011951.1
Saccharomyces cerevisiae
SSA1

Selected references

External links

EPD
HS_HSPA8
ORF Accession
NM_006597
CDS Accession
NP_006588
OMIM
600816
HPRD
07205
Ensembl
HSPA8
UniProt/Swiss-Prot
HSP7C_HUMAN
GeneCards
HSPA8
Entrez Gene
3312
UniGene
702021
GenAtlas
HSPA8
Internet
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