GenAge entry for PML (Homo sapiens)

Gene name (HAGRID: 96)

HGNC symbol
PML 
Aliases
MYL; TRIM19; RNF71 
Common name
promyelocytic leukemia 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

The PML gene encodes a number of transcripts and can function as a transcription factor. It is likely oncogenic and may act as a tumour suppressor [518]. PML also appears to control cell proliferation and cellular senescence [517], though its role, if any, in human ageing is unknown.

Cytogenetic information

Cytogenetic band
15q22
Location
73,994,673 bp to 74,047,814 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001666; response to hypoxia
GO:0001932; regulation of protein phosphorylation
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0006461; protein complex assembly
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050; cell cycle arrest
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007182; common-partner SMAD protein phosphorylation
GO:0007184; SMAD protein import into nucleus
And 42 more GO terms
Cellular component: GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016363; nuclear matrix
GO:0016605; PML body
GO:0031901; early endosome membrane
GO:0031965; nuclear membrane
GO:0042406; extrinsic component of endoplasmic reticulum membrane
And 1 more GO terms
Function: GO:0003677; DNA binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0031625; ubiquitin protein ligase binding
GO:0032183; SUMO binding
GO:0042803; protein homodimerization activity
GO:0046332; SMAD binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TERT, WRN, LMNA, STAT3, HDAC3, MYC, EGFR, NCOR1, FOS, PIN1, CREBBP, BCL2, NR3C1, TOP2B, NFKB1, RAD51, UBE2I, PML, HTT, FAS, RB1, FOXO1, RELA, SIRT1, HDAC1, SP1, JUN, MAPK3, ATF2, SIN3A, CDK1, HDAC2, MDM2, SUMO1, H2AFX, MTOR, CTNNB1, CDKN2A, TP63, CHEK2, PPARGC1A, PPARG, NCOR2, SQSTM1
STRING interaction network
Protein-Protein network diagram for PML

Retrieve sequences for PML

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Pml
Rattus norvegicus
Pml

In other databases

CellAge
  • This gene is present as PML

Selected references

External links

EPD
ORF Accession
NM_033238
CDS Accession
NP_150241
OMIM
102578
HPRD
00023
Ensembl
PML
UniProt/Swiss-Prot
PML_HUMAN
GeneCards
PML
Entrez Gene
5371
GenAtlas
PML
Internet
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