GenAge entry for GRB2 (Homo sapiens)

Gene name (HAGRID: 122)

HGNC symbol
GRB2 
Aliases
NCKAP2 
Common name
growth factor receptor-bound protein 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

An important player in growth signalling pathways, GRB2's functions are not yet well understood. Analyses of mice with a null mutation in GRB2 suggest that GRB2 is required for embryonic development and malignant transformation [620]. Due to its role as a signal transducer of many pathways, including pathways and genes previously related to ageing such as INS/IGF1 signalling and SHC1 [1107], it is possible GRB2 plays some role in ageing.

Cytogenetic information

Cytogenetic band
17q24-q25
Location
75,318,076 bp to 75,405,708 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007265; Ras protein signal transduction
GO:0007267; cell-cell signaling
GO:0007411; axon guidance
GO:0007568; aging
GO:0008286; insulin receptor signaling pathway
GO:0008543; fibroblast growth factor receptor signaling pathway
GO:0009967; positive regulation of signal transduction
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0016032; viral process
And 20 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005768; endosome
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0008180; COP9 signalosome
GO:0012506; vesicle membrane
And 3 more GO terms
Function: GO:0001784; phosphotyrosine binding
GO:0005070; SH3/SH2 adaptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005154; epidermal growth factor receptor binding
GO:0005168; neurotrophin TRKA receptor binding
GO:0005515; protein binding
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0017124; SH3 domain binding
GO:0019901; protein kinase binding
GO:0019903; protein phosphatase binding
GO:0042802; identical protein binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHR, SHC1, PTPN11, IRS1, PTPN1, IRS2, PIK3CB, EGFR, ERBB2, INSR, PDGFRB, EPOR, PPARA, RET, HSP90AA1, ABL1, EP300, HTT, HSPA8, RB1, GRB2, A2M, HSPD1, HSPA1B, YWHAZ, PTK2B, PTK2, MAPK9, PIK3R1, JAK2, HSPA9, VCP, CLU, DBN1, PPP1CA, CDC42, EPS8, PDGFRA, PIK3CA
STRING interaction network
Protein-Protein network diagram for GRB2

Retrieve sequences for GRB2

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
sem-5
Danio rerio
grb2a
Danio rerio
grb2b
Drosophila melanogaster
drk
Mus musculus
Grb2
Rattus norvegicus
Grb2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as sem-5
LongevityMap
  • This gene is present as GRB2

Selected references

External links

EPD
ORF Accession
NM_002086
CDS Accession
NP_002077
OMIM
108355
HPRD
00150
Ensembl
GRB2
UniProt/Swiss-Prot
GRB2_HUMAN
GeneCards
GRB2
Entrez Gene
2885
UniGene
444356
GenAtlas
GRB2
Internet
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