GenAge entry for TNF (Homo sapiens)
Gene name (HAGRID: 86)
- HGNC symbol
- TNF
- Aliases
- TNFSF2; DIF; TNF-alpha; TNFA
- Common name
- tumor necrosis factor
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
A cytokine involved in the immune response, TNF can induce cell death in some tumour cells. It can also induce cellular proliferation and differentiation [493].
TNF-deficient mice develop normally but are more susceptible to some infectious agents [493]. Other results from mice suggest that TNF may protect neurons by stimulating antioxidant pathways [492]. There is an association between TNF levels and age [715], though human polymorphisms in TNF have not been associated with longevity [221]. Although TNF may be associated with human age-related diseases, such as dementia [1168], more studies are necessary to establish what is TNF's involvement in human ageing.
Cytogenetic information
- Cytogenetic band
- 6p21.3
- Location
- 2,917,465 bp to 2,920,233 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000060; protein import into nucleus, translocation
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000165; MAPK cascade
GO:0000185; activation of MAPKKK activity
GO:0000187; activation of MAPK activity
GO:0001819; positive regulation of cytokine production
GO:0001934; positive regulation of protein phosphorylation
GO:0001937; negative regulation of endothelial cell proliferation
GO:0002439; chronic inflammatory response to antigenic stimulus
GO:0002740; negative regulation of cytokine secretion involved in immune response
GO:0002876; positive regulation of chronic inflammatory response to antigenic stimulus
And 107 more GO terms Cellular component: GO:0001891; phagocytic cup
GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009897; external side of plasma membrane
GO:0009986; cell surface
GO:0045121; membrane raft
GO:0055037; recycling endosome
Function: GO:0002020; protease binding
GO:0005125; cytokine activity
GO:0005164; tumor necrosis factor receptor binding
GO:0005515; protein binding
GO:0042802; identical protein binding
GO:0044212; transcription regulatory region DNA binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TNF, FAS, NFKBIA, CLU, CDC42, IKBKB
- STRING interaction network
Retrieve sequences for TNF
Homologs in model organisms
- Danio rerio
- tnfb
- Danio rerio
- tnfa
- Mus musculus
- Tnf
- Rattus norvegicus
- LOC103694380
- Rattus norvegicus
- Tnf
In other databases
- LongevityMap
- This gene is present as TNF