GenAge entry for PDGFRA (Homo sapiens)

Gene name (HAGRID: 285)

HGNC symbol
PDGFRA 
Aliases
CD140a; PDGFR2 
Common name
platelet-derived growth factor receptor, alpha polypeptide 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

The PDGFRA gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. PDGFRA binds PDGFB and thus may be related to age-related changes in the heart [363]. With age, there is a decline in the PDGFRA levels of beta-cell in mice, accompanied by a reduction in beta-cell replication. The conditional inactivation of Pdgfra accelerates these changes, preventing neonatal beta-cell expansion and adult beta-cell regeneration. Similar results were observed in human beta-cells [2224]. Receptor tyrosine kinases have been found to be expressed in metastatic colon cancer [2225] and PDGFRA mutations were found in gastrointestinal tumours [2226]. PDGFRA has not been directly related to ageing, however.

Cytogenetic information

Cytogenetic band
4q12
Location
54,229,097 bp to 54,298,245 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0001553; luteinization
GO:0001701; in utero embryonic development
GO:0001775; cell activation
GO:0002244; hematopoietic progenitor cell differentiation
GO:0007204; positive regulation of cytosolic calcium ion concentration
GO:0008210; estrogen metabolic process
GO:0008284; positive regulation of cell proliferation
GO:0010544; negative regulation of platelet activation
GO:0010863; positive regulation of phospholipase C activity
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
And 39 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0005902; microvillus
GO:0009897; external side of plasma membrane
GO:0016020; membrane
GO:0031226; intrinsic component of plasma membrane
GO:0043234; protein complex
Function: GO:0004672; protein kinase activity
GO:0004714; transmembrane receptor protein tyrosine kinase activity
GO:0005018; platelet-derived growth factor alpha-receptor activity
GO:0005021; vascular endothelial growth factor-activated receptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005161; platelet-derived growth factor receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0032403; protein complex binding
GO:0038085; vascular endothelial growth factor binding
GO:0042803; protein homodimerization activity
And 3 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
STAT3, EGFR, PDGFB, PDGFRB, PTEN, GRB2, PIK3R1, CLU, PDGFRA
STRING interaction network
Protein-Protein network diagram for PDGFRA

Retrieve sequences for PDGFRA

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
pdgfra
Drosophila melanogaster
Pvr
Mus musculus
Pdgfra
Rattus norvegicus
Pdgfra

Selected references

External links

EPD
ORF Accession
NM_006206
CDS Accession
NP_006197
OMIM
173490
HPRD
01429
Ensembl
PDGFRA
UniProt/Swiss-Prot
PGFRA_HUMAN
GeneCards
PDGFRA
Entrez Gene
5156
UniGene
74615
GenAtlas
PDGFRA
Internet
Search Google