GenAge entry for MT-CO1 (Homo sapiens)

Gene name (HAGRID: 158)

HGNC symbol
MT-CO1 
Aliases
COX1; COI; MTCO1 
Common name
mitochondrially encoded cytochrome c oxidase I 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

Encoded in the mitochondrial DNA, MT-CO1 catalyses the reduction of oxygen to water. COX1, a homologue of MT-CO1, has been related to longevity in the filamentous fungus Podospora anserina [207]. Mutations in the human MT-CO1 gene have been associated with several diseases, including neurodegenerative diseases [751]. Further research is necessary to understand whether MT-CO1 is involved in human ageing.

Cytogenetic information

Cytogenetic band
Location
7,444 bp to 7,518 bp
Orientation
Unknown
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process:
Cellular component:
Function:
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
CDC42
STRING interaction network
Protein-Protein network diagram for MT-CO1

Retrieve sequences for MT-CO1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
ctc-1
Danio rerio
mt-co1
Drosophila melanogaster
mt:CoI
Mus musculus
mt-Co1
Rattus norvegicus
Mt-co1
Saccharomyces cerevisiae
COX1
Schizosaccharomyces pombe
cox1

Selected references

External links

EPD
ORF Accession
NM_173704
CDS Accession
NP_776052
OMIM
516030
HPRD
02469
Ensembl
MT-CO1
UniProt/Swiss-Prot
COX1_HUMAN
GeneCards
MT-CO1
Entrez Gene
4512
UniGene
GenAtlas
MT-CO1
Internet
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