GenAge entry for MAPK3 (Homo sapiens)

Gene name (HAGRID: 175)

HGNC symbol
MAPK3 
Aliases
ERK1; p44mapk; p44erk1; PRKM3 
Common name
mitogen-activated protein kinase 3 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Also called ERK1, MAPK3 is involved in stress response signalling and maybe in cell cycle control. MAPK3-null mice are viable and fertile but have defective thymocyte maturation [788]. Changes in stress response have been reported during murine ageing that could be a result of changes in MAPK3 [346]. The relevance of MAPK3 to human ageing remains undetermined.

Cytogenetic information

Cytogenetic band
16p11.2
Location
30,114,105 bp to 30,123,309 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0000187; activation of MAPK activity
GO:0000189; MAPK import into nucleus
GO:0001934; positive regulation of protein phosphorylation
GO:0006361; transcription initiation from RNA polymerase I promoter
GO:0006461; protein complex assembly
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
GO:0006975; DNA damage induced protein phosphorylation
GO:0007049; cell cycle
GO:0007411; axon guidance
And 49 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005635; nuclear envelope
GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0005769; early endosome
GO:0005770; late endosome
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0005856; cytoskeleton
GO:0005901; caveola
GO:0005925; focal adhesion
And 5 more GO terms
Function: GO:0001784; phosphotyrosine binding
GO:0004674; protein serine/threonine kinase activity
GO:0004707; MAP kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016301; kinase activity
GO:0019902; phosphatase binding
GO:0097110; scaffold protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, MYC, INSR, RET, BRCA1, CREBBP, VCP, PML, HTT, SNCG, MAPK14, SP1, JUN, MAPK3, ATF2, PTGS2, SIRT6, CHEK2, TP53BP1, HTRA2
STRING interaction network
Protein-Protein network diagram for MAPK3

Retrieve sequences for MAPK3

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
mpk-1
Danio rerio
mapk3
Drosophila melanogaster
rl
Mus musculus
Mapk3
Rattus norvegicus
Mapk3
Saccharomyces cerevisiae
KSS1
Saccharomyces cerevisiae
FUS3
Schizosaccharomyces pombe
spk1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as KSS1
  • A homolog of this gene for Caenorhabditis elegans is present as mpk-1
LongevityMap
  • This gene is present as MAPK3

Selected references

External links

EPD
ORF Accession
NM_002746
CDS Accession
NP_002737
OMIM
601795
HPRD
03479
Ensembl
MAPK3
UniProt/Swiss-Prot
MK03_HUMAN
GeneCards
MAPK3
Entrez Gene
5595
UniGene
861
GenAtlas
MAPK3
Internet
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