GenAge entry for FAS (Homo sapiens)
Gene name (HAGRID: 115)
- HGNC symbol
- FAS
- Aliases
- CD95; APO-1; FAS1; APT1; TNFRSF6
- Common name
- Fas cell surface death receptor
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
FAS encodes multiple transcripts involved in apoptosis and development. It is also related to cancer progression. The expression level of FAS changes during ageing [937], and there are some results correlating FAS with age-related changes [1170]. Nonetheless, polymorphisms in human FAS have not been associated with human longevity [935].
Cytogenetic information
- Cytogenetic band
- 10q24.1
- Location
- 88,990,531 bp to 89,015,785 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0002377; immunoglobulin production
GO:0003014; renal system process
GO:0006461; protein complex assembly
GO:0006915; apoptotic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006924; activation-induced cell death of T cells
GO:0006925; inflammatory cell apoptotic process
GO:0006954; inflammatory response
GO:0006955; immune response
GO:0007165; signal transduction
GO:0007420; brain development
And 36 more GO terms Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0009897; external side of plasma membrane
GO:0009986; cell surface
GO:0031264; death-inducing signaling complex
GO:0031265; CD95 death-inducing signaling complex
GO:0043005; neuron projection
GO:0045121; membrane raft
And 2 more GO terms Function: GO:0004871; signal transducer activity
GO:0004872; receptor activity
GO:0005031; tumor necrosis factor-activated receptor activity
GO:0005515; protein binding
GO:0019900; kinase binding
GO:0042802; identical protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- UBE2I, TNF, PML, PRKCA, FAS, RB1, MAPK8, MAP3K5, EEF1A1, SUMO1, CTNNB1, TP63, SQSTM1
- STRING interaction network
Retrieve sequences for FAS
Homologs in model organisms
In other databases
Selected references
External links
- EPD
- ORF Accession
- NM_000043
- CDS Accession
- NP_000034
- OMIM
- 134637
- HPRD
- 00609
- Ensembl
- FAS
- UniProt/Swiss-Prot
- TNR6_HUMAN
- GeneCards
- FAS
- Entrez Gene
- 355
- GenAtlas
- FAS
- Internet
- Search Google