GenAge entry for IRS1 (Homo sapiens)
Gene name (HAGRID: 32)
- HGNC symbol
- IRS1
- Aliases
- HIRS-1
- Common name
- insulin receptor substrate 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
- Description
IRS1 and IRS2 mediate many of the cellular actions of insulin (INS). Results from model organisms suggest IRS1 is involved in the IGF1/GH1 axis that could regulate ageing. In Drosophila, loss of chico, an insulin receptor substrate, extends lifespan [188]. Median lifespan was extended 18% in knockout mice from both sexes and 32% in females. Female animals displayed signs of resistance to ageing markers in skin, bone, immune system, and motor dysfunction, in spite of mild, lifelong insulin resistance. Heterozygous animals had normal lifespans [1924]. IRS1 may also be involved in the extended lifespan of some mouse strains [292]. In humans, mutations in IRS1 have been associated with diabetes [1658] and atherosclerosis [1657]. While it appears that IRS1 plays a role in some human age-related pathologies, its exact impact on the human ageing process is unknown.
Cytogenetic information
- Cytogenetic band
- 2q36
- Location
- 226,731,317 bp to 226,798,790 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000165; MAPK cascade
GO:0007165; signal transduction
GO:0008284; positive regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0010907; positive regulation of glucose metabolic process
GO:0014065; phosphatidylinositol 3-kinase signaling
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0032000; positive regulation of fatty acid beta-oxidation
GO:0032868; response to insulin
GO:0032869; cellular response to insulin stimulus
GO:0036092; phosphatidylinositol-3-phosphate biosynthetic process
And 14 more GO terms Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005899; insulin receptor complex
GO:0005901; caveola
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0004871; signal transducer activity
GO:0005068; transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080; protein kinase C binding
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005158; insulin receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005515; protein binding
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0042169; SH2 domain binding
GO:0043548; phosphatidylinositol 3-kinase binding
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
And 1 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- IGF1R, PTPN11, PTPN1, IRS2, AKT1, PIK3CB, EGFR, ERBB2, INSR, PRKCD, PLCG2, BCL2, GRB2, APP, SIRT1, MAPK8, PTK2, PIK3R1, HDAC2, JAK2, ESR1, MTOR, PIK3CA, IKBKB
- STRING interaction network
Retrieve sequences for IRS1
Homologs in model organisms
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as chico
- LongevityMap
- This gene is present as IRS1
Selected references
External links
- EPD
- ORF Accession
- NM_005544
- CDS Accession
- NP_005535
- OMIM
- 147545
- HPRD
- 00943
- Ensembl
- IRS1
- UniProt/Swiss-Prot
- IRS1_HUMAN
- GeneCards
- IRS1
- Entrez Gene
- 3667
- GenAtlas
- IRS1
- Internet
- Search Google