GenAge entry for IRS1 (Homo sapiens)

Gene name (HAGRID: 32)

HGNC symbol
IRS1 
Aliases
HIRS-1 
Common name
insulin receptor substrate 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

IRS1 and IRS2 mediate many of the cellular actions of insulin (INS). Results from model organisms suggest IRS1 is involved in the IGF1/GH1 axis that could regulate ageing. In Drosophila, loss of chico, an insulin receptor substrate, extends lifespan [188]. Median lifespan was extended 18% in knockout mice from both sexes and 32% in females. Female animals displayed signs of resistance to ageing markers in skin, bone, immune system, and motor dysfunction, in spite of mild, lifelong insulin resistance. Heterozygous animals had normal lifespans [1924]. IRS1 may also be involved in the extended lifespan of some mouse strains [292]. In humans, mutations in IRS1 have been associated with diabetes [1658] and atherosclerosis [1657]. While it appears that IRS1 plays a role in some human age-related pathologies, its exact impact on the human ageing process is unknown.

Cytogenetic information

Cytogenetic band
2q36
Location
226,731,317 bp to 226,798,790 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0007165; signal transduction
GO:0008284; positive regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0010907; positive regulation of glucose metabolic process
GO:0014065; phosphatidylinositol 3-kinase signaling
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0032000; positive regulation of fatty acid beta-oxidation
GO:0032868; response to insulin
GO:0032869; cellular response to insulin stimulus
GO:0036092; phosphatidylinositol-3-phosphate biosynthetic process
And 14 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005899; insulin receptor complex
GO:0005901; caveola
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0004871; signal transducer activity
GO:0005068; transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005080; protein kinase C binding
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005158; insulin receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005515; protein binding
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0042169; SH2 domain binding
GO:0043548; phosphatidylinositol 3-kinase binding
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity
And 1 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
IGF1R, PTPN11, PTPN1, IRS2, AKT1, PIK3CB, EGFR, ERBB2, INSR, PRKCD, PLCG2, BCL2, GRB2, APP, SIRT1, MAPK8, PTK2, PIK3R1, HDAC2, JAK2, ESR1, MTOR, PIK3CA, IKBKB
STRING interaction network
Protein-Protein network diagram for IRS1

Retrieve sequences for IRS1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
irs1
Drosophila melanogaster
chico
Mus musculus
Irs1
Rattus norvegicus
Irs1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as chico
  • A homolog of this gene for Mus musculus is present as Irs1
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as chico
LongevityMap
  • This gene is present as IRS1

Selected references

External links

EPD
ORF Accession
NM_005544
CDS Accession
NP_005535
OMIM
147545
HPRD
00943
Ensembl
IRS1
UniProt/Swiss-Prot
IRS1_HUMAN
GeneCards
IRS1
Entrez Gene
3667
UniGene
471508
GenAtlas
IRS1
Internet
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