GenAge entry for TCF3 (Homo sapiens)
Gene name (HAGRID: 59)
- HGNC symbol
- TCF3
- Aliases
- E2A; ITF1; MGC129647; MGC129648; bHLHb21; VDIR; E47
- Common name
- transcription factor 3
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
A crucial protein in development, TCF3 may be involved in ageing of the immune system [1529].
Cytogenetic information
- Cytogenetic band
- 19p13.3
- Location
- 1,609,290 bp to 1,652,329 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0002326; B cell lineage commitment
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0030183; B cell differentiation
GO:0033152; immunoglobulin V(D)J recombination
GO:0045666; positive regulation of neuron differentiation
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0051091; positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051149; positive regulation of muscle cell differentiation
And 1 more GO terms Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0090575; RNA polymerase II transcription factor complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0031435; mitogen-activated protein kinase kinase kinase binding
GO:0035326; enhancer binding
GO:0042803; protein homodimerization activity
GO:0043425; bHLH transcription factor binding
And 5 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TCF3, PARP1, CREBBP, UBE2I, EP300, RB1, HDAC2
- STRING interaction network
Retrieve sequences for TCF3
Homologs in model organisms
- Caenorhabditis elegans
- hlh-2
- Danio rerio
- tcf3b
- Danio rerio
- tcf3a
- Drosophila melanogaster
- da
- Mus musculus
- Tcf3
- Rattus norvegicus
- Tcf3
In other databases
- CellAge gene expression
- This gene is present as TCF3
Selected references
External links
- EPD
- ORF Accession
- NM_003200
- CDS Accession
- NP_003191
- OMIM
- 147141
- HPRD
- 00918
- Ensembl
- TCF3
- UniProt/Swiss-Prot
- TFE2_HUMAN
- GeneCards
- TCF3
- Entrez Gene
- 6929
- GenAtlas
- TCF3
- Internet
- Search Google