GenAge entry for PDPK1 (Homo sapiens)

Gene name (HAGRID: 87)

HGNC symbol
PDPK1 
Aliases
PDK1 
Common name
3-phosphoinositide dependent protein kinase 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

PDPK1 phosphorylates and activates AKT1, among other proteins, and appears to play a role in signal transduction and development, maybe by mediating the activation of AKT1 by growth factors. The PDPK1 encodes three isoforms. In roundworms, PDPK1 has been associated with signals related to development and longevity [948]. Mice without PDPK1 die at embryonic stages, though mice with low levels of PDPK1 are viable and fertile despite a small body size [1633].

Cytogenetic information

Cytogenetic band
16p13.3
Location
2,537,964 bp to 2,603,190 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0003323; type B pancreatic cell development
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0006468; protein phosphorylation
GO:0006469; negative regulation of protein kinase activity
GO:0006972; hyperosmotic response
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0010518; positive regulation of phospholipase activity
GO:0010594; regulation of endothelial cell migration
GO:0010667; negative regulation of cardiac muscle cell apoptotic process
And 26 more GO terms
Cellular component: GO:0005622; intracellular
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005925; focal adhesion
GO:0014069; postsynaptic density
GO:0016020; membrane
GO:0031410; cytoplasmic vesicle
GO:0042995; cell projection
GO:0043204; perikaryon
And 1 more GO terms
Function: GO:0004674; protein serine/threonine kinase activity
GO:0004676; 3-phosphoinositide-dependent protein kinase activity
GO:0005158; insulin receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0016004; phospholipase activator activity
GO:0016301; kinase activity
GO:0019901; protein kinase binding
GO:0043274; phospholipase binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
AKT1, PRKCD, PDPK1, XRCC6, APP, MAPK8
STRING interaction network
Protein-Protein network diagram for PDPK1

Retrieve sequences for PDPK1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
pdk-1
Danio rerio
pdpk1a
Danio rerio
pdpk1b
Drosophila melanogaster
Pdk1
Mus musculus
Pdpk1
Rattus norvegicus
Pdpk1
Saccharomyces cerevisiae
PKH2
Saccharomyces cerevisiae
PKH3
Saccharomyces cerevisiae
PKH1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as pdk-1
  • A homolog of this gene for Saccharomyces cerevisiae is present as PKH1
  • A homolog of this gene for Saccharomyces cerevisiae is present as PKH3
  • A homolog of this gene for Saccharomyces cerevisiae is present as PKH2
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as PKH2
LongevityMap
  • This gene is present as PDPK1
CellAge
  • This gene is present as PDPK1

Selected references

External links

EPD
ORF Accession
NM_002613
CDS Accession
NP_002604
OMIM
605213
HPRD
05556
Ensembl
PDPK1
UniProt/Swiss-Prot
PDPK1_HUMAN
GeneCards
PDPK1
Entrez Gene
5170
UniGene
459691
GenAtlas
PDPK1
Internet
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