GenAge entry for MED1 (Homo sapiens)

Gene name (HAGRID: 173)

HGNC symbol
MED1 
Aliases
PBP; TRAP220; RB18A; DRIP230; CRSP200; CRSP1; TRIP2; PPARGBP; PPARBP 
Common name
mediator complex subunit 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

MED1 is a transcriptional coactivator involved in embryonic development and important for SP1 activity [785]. MED1-null mice die at embryonic stages [785]. Certain age-related pathologies, such as heart disease, may be related to PPARs [392], but it unclear whether MED1 is a major player in human ageing.

Cytogenetic information

Cytogenetic band
17q12
Location
39,404,285 bp to 39,451,274 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000902; cell morphogenesis
GO:0001525; angiogenesis
GO:0001889; liver development
GO:0001892; embryonic placenta development
GO:0002088; lens development in camera-type eye
GO:0002154; thyroid hormone mediated signaling pathway
GO:0003222; ventricular trabecula myocardium morphogenesis
GO:0003406; retinal pigment epithelium development
GO:0006356; regulation of transcription from RNA polymerase I promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
And 47 more GO terms
Cellular component: GO:0000151; ubiquitin ligase complex
GO:0000785; chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0016020; membrane
GO:0016592; mediator complex
GO:0032993; protein-DNA complex
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981; RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001047; core promoter binding
GO:0001104; RNA polymerase II transcription cofactor activity
GO:0003682; chromatin binding
GO:0003712; transcription cofactor activity
GO:0003713; transcription coactivator activity
GO:0004872; receptor activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0016922; ligand-dependent nuclear receptor binding
And 13 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
POU1F1, TP53, ATM, MYC, PARP1, PIN1, NR3C1, AR, MED1, MDM2, ESR1, PPARGC1A, PPARG
STRING interaction network
Protein-Protein network diagram for MED1

Retrieve sequences for MED1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
med1
Drosophila melanogaster
MED1
Mus musculus
Med1
Rattus norvegicus
Med1

Selected references

External links

EPD
ORF Accession
NM_004774
CDS Accession
NP_004765
OMIM
604311
HPRD
05055
Ensembl
MED1
UniProt/Swiss-Prot
MED1_HUMAN
GeneCards
MED1
Entrez Gene
5469
GenAtlas
MED1
Internet
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