GenAge entry for DDIT3 (Homo sapiens)

Gene name (HAGRID: 203)

HGNC symbol
DDIT3 
Aliases
CHOP10; GADD153; CHOP 
Common name
DNA-damage-inducible transcript 3 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

Also called GADD153 and CHOP, DDIT3 prevents transcription in response to DNA damage [880]. It also appears to be related to apoptosis. Although DDIT3 levels may increase with age [879], its relation to human ageing remains undetermined.

Cytogenetic information

Cytogenetic band
12q13.1-q1
Location
57,516,588 bp to 57,520,517 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001955; blood vessel maturation
GO:0006355; regulation of transcription, DNA-templated
GO:0006974; cellular response to DNA damage stimulus
GO:0006983; ER overload response
GO:0006986; response to unfolded protein
GO:0007050; cell cycle arrest
GO:0016055; Wnt signaling pathway
GO:0032757; positive regulation of interleukin-8 production
GO:0032792; negative regulation of CREB transcription factor activity
GO:0034976; response to endoplasmic reticulum stress
And 26 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005770; late endosome
GO:0005829; cytosol
GO:0032993; protein-DNA complex
GO:0035976; transcription factor AP-1 complex
GO:0036488; CHOP-C/EBP complex
GO:1990617; CHOP-ATF4 complex
GO:1990622; CHOP-ATF3 complex
Function: GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003714; transcription corepressor activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008140; cAMP response element binding protein binding
GO:0042803; protein homodimerization activity
GO:0043522; leucine zipper domain binding
And 3 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
JUND, FOS, CREBBP, CEBPB, EP300, HDAC1, MAPK14, JUN, ATF2, DDIT3
STRING interaction network
Protein-Protein network diagram for DDIT3

Retrieve sequences for DDIT3

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ddit3
Mus musculus
Ddit3
Rattus norvegicus
Ddit3

Selected references

External links

EPD
ORF Accession
NM_004083
CDS Accession
NP_004074
OMIM
126337
HPRD
00529
Ensembl
DDIT3
UniProt/Swiss-Prot
DDIT3_HUMAN
GeneCards
DDIT3
Entrez Gene
1649
GenAtlas
DDIT3
Internet
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