GenAge entry for FOS (Homo sapiens)

Gene name (HAGRID: 50)

HGNC symbol
FOS 
Aliases
c-fos; AP-1 
Common name
FBJ murine osteosarcoma viral oncogene homolog 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

The FOS oncogene plays an important role in development, cell proliferation, and differentiation [118]. As part of the AP-1 transcriptional complex, FOS has been associated with age-related changes and with the attenuated cellular response in older cells [851]. Still, its relevance to human ageing remains under debate.

Cytogenetic information

Cytogenetic band
14q24.3
Location
75,278,778 bp to 75,282,234 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001661; conditioned taste aversion
GO:0006306; DNA methylation
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0006954; inflammatory response
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007399; nervous system development
GO:0007565; female pregnancy
GO:0007568; aging
GO:0009409; response to cold
GO:0009416; response to light stimulus
And 24 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0016020; membrane
GO:0043005; neuron projection
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0044212; transcription regulatory region DNA binding
GO:0046982; protein heterodimerization activity
GO:0070412; R-SMAD binding
And 1 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
EGFR, JUND, FOS, CREBBP, ABL1, UBE2I, CEBPA, EP300, PML, RB1, APP, RELA, SIRT1, HSPA1A, JUN, MAPK9, TAF1, ATF2, TBP, DDIT3, ESR1, CLU, CHEK2, NCOR2
STRING interaction network
Protein-Protein network diagram for FOS

Retrieve sequences for FOS

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
fosaa
Danio rerio
FOS (1 of many)
Drosophila melanogaster
kay
Mus musculus
Fos
Rattus norvegicus
Fos

In other databases

CellAge
  • This gene is present as FOS

Selected references

External links

EPD
HS_FOS
ORF Accession
NM_005252
CDS Accession
NP_005243
OMIM
164810
HPRD
01275
Ensembl
FOS
UniProt/Swiss-Prot
FOS_HUMAN
GeneCards
FOS
Entrez Gene
2353
UniGene
25647
GenAtlas
FOS
Internet
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