GenAge entry for VCP (Homo sapiens)

Gene name (HAGRID: 71)

HGNC symbol
VCP 
Aliases
IBMPFD; p97 
Common name
valosin containing protein 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Also known as p97, VCP is required for the export of endoplasmic reticulum proteins into the cytosol [455]. Its interaction with WRN and a possible role in WRN's DNA damage response pathway makes it an intriguing protein [454], even though it has not been directly linked to ageing.

Cytogenetic information

Cytogenetic band
9p13.3
Location
35,056,068 bp to 35,072,742 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006281; DNA repair
GO:0006302; double-strand break repair
GO:0006734; NADH metabolic process
GO:0006888; ER to Golgi vesicle-mediated transport
GO:0006914; autophagy
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974; cellular response to DNA damage stimulus
GO:0010918; positive regulation of mitochondrial membrane potential
GO:0016567; protein ubiquitination
GO:0018279; protein N-linked glycosylation via asparagine
GO:0019079; viral genome replication
And 26 more GO terms
Cellular component: GO:0000502; proteasome complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0005811; lipid particle
GO:0005829; cytosol
GO:0034098; VCP-NPL4-UFD1 AAA ATPase complex
GO:0035861; site of double-strand break
GO:0036513; Derlin-1 retrotranslocation complex
And 6 more GO terms
Function: GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008289; lipid binding
GO:0016887; ATPase activity
GO:0019903; protein phosphatase binding
GO:0019904; protein domain specific binding
GO:0031593; polyubiquitin binding
GO:0031625; ubiquitin protein ligase binding
GO:0035800; deubiquitinase activator activity
GO:0036435; K48-linked polyubiquitin binding
GO:0042288; MHC class I protein binding
And 7 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ERCC8, WRN, LMNA, NFKB2, AKT1, PRKCD, BRCA1, HIF1A, BLM, HSP90AA1, NFKB1, TOP1, ERCC6, HTT, AR, TERF2, HSPA8, BAX, GRB2, HSPD1, HSPA1A, YWHAZ, MAPK3, PTGS2, CDK1, MDM2, VCP, UBB, SUMO1, HELLS, ESR1, NFKBIA, MTOR, TP63, STUB1, CHEK2, SIRT7, TP53BP1, CDKN1A, HTRA2, SPRTN
STRING interaction network
Protein-Protein network diagram for VCP

Retrieve sequences for VCP

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
cdc-48.1
Caenorhabditis elegans
cdc-48.2
Danio rerio
vcp
Drosophila melanogaster
TER94
Mus musculus
Vcp
Rattus norvegicus
Vcp
Saccharomyces cerevisiae
CDC48
Schizosaccharomyces pombe
cdc48

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as cdc-48.1

Selected references

External links

EPD
HS_VCP_2
ORF Accession
NM_007126
CDS Accession
NP_009057
OMIM
601023
HPRD
03013
Ensembl
VCP
UniProt/Swiss-Prot
TERA_HUMAN
GeneCards
VCP
Entrez Gene
7415
UniGene
529782
GenAtlas
VCP
Internet
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