GenAge entry for SDHC (Homo sapiens)

Gene name (HAGRID: 182)

HGNC symbol
SDHC 
Aliases
CYB560; PGL3 
Common name
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

A member of the mitochondrial electron transport chain, SDHC homologues have been implicated in ageing of lower life forms. In roundworms, mutations in a SDHC homologue have been reported to cause oxidative stress and premature ageing [799]. Mutations in the human SDHC gene have been associated with mitochondrial respiratory chain deficiency [798], but not with premature ageing. Whether SDHC influences human ageing has not been determined.

Cytogenetic information

Cytogenetic band
1q23.3
Location
161,314,376 bp to 161,364,745 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006099; tricarboxylic acid cycle
GO:0006121; mitochondrial electron transport, succinate to ubiquinone
GO:0009060; aerobic respiration
GO:0055114; oxidation-reduction process
Cellular component: GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005749; mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
GO:0016021; integral component of membrane
GO:0045273; respiratory chain complex II
Function: GO:0000104; succinate dehydrogenase activity
GO:0009055; electron carrier activity
GO:0020037; heme binding
GO:0046872; metal ion binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
XRCC6, MDM2
STRING interaction network
Protein-Protein network diagram for SDHC

Retrieve sequences for SDHC

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
mev-1
Danio rerio
sdhc
Drosophila melanogaster
CG6629
Drosophila melanogaster
SdhC
Mus musculus
Sdhc
Rattus norvegicus
Sdhc
Schizosaccharomyces pombe
sdh3

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as mev-1
  • A homolog of this gene for Drosophila melanogaster is present as SdhC

Selected references

External links

EPD
HS_SDHC
ORF Accession
NM_003001
CDS Accession
NP_002992
OMIM
602413
HPRD
03878
Ensembl
SDHC
UniProt/Swiss-Prot
C560_HUMAN
GeneCards
SDHC
Entrez Gene
6391
UniGene
444472
GenAtlas
SDHC
Internet
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