GenAge entry for PDGFRB (Homo sapiens)

Gene name (HAGRID: 51)

HGNC symbol
PDGFRB 
Aliases
JTK12; CD140b; PDGFR1; PDGFR 
Common name
platelet-derived growth factor receptor, beta polypeptide 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

PDGFRB binds PDGFB and thus may be related to age-related changes in the heart [363]. PDGFRB is also an important player in development [379].

Cytogenetic information

Cytogenetic band
5q33.1
Location
150,113,839 bp to 150,155,859 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0006024; glycosaminoglycan biosynthetic process
GO:0007165; signal transduction
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007568; aging
GO:0008284; positive regulation of cell proliferation
GO:0008584; male gonad development
GO:0009636; response to toxic substance
GO:0010863; positive regulation of phospholipase C activity
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling
And 54 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005886; plasma membrane
GO:0005925; focal adhesion
GO:0009986; cell surface
GO:0016020; membrane
GO:0016021; integral component of membrane
GO:0016324; apical plasma membrane
GO:0031226; intrinsic component of plasma membrane
GO:0031410; cytoplasmic vesicle
GO:0043202; lysosomal lumen
And 2 more GO terms
Function: GO:0004713; protein tyrosine kinase activity
GO:0004992; platelet activating factor receptor activity
GO:0005017; platelet-derived growth factor-activated receptor activity
GO:0005019; platelet-derived growth factor beta-receptor activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005102; receptor binding
GO:0005161; platelet-derived growth factor receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019899; enzyme binding
GO:0019901; protein kinase binding
And 5 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, PTPN11, STAT3, STAT5A, EGFR, PDGFB, PDGFRB, PTEN, HSP90AA1, GRB2, PIK3R1, PDGFRA
STRING interaction network
Protein-Protein network diagram for PDGFRB

Retrieve sequences for PDGFRB

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
PDGFRB
Drosophila melanogaster
Pvr
Mus musculus
Pdgfrb
Rattus norvegicus
Pdgfrb

Selected references

External links

EPD
ORF Accession
NM_002609
CDS Accession
NP_002600
OMIM
173410
HPRD
01423
Ensembl
PDGFRB
UniProt/Swiss-Prot
PGFRB_HUMAN
GeneCards
PDGFRB
Entrez Gene
5159
UniGene
509067
GenAtlas
PDGFRB
Internet
Search Google