GenAge entry for STAT5A (Homo sapiens)
Gene name (HAGRID: 23)
- HGNC symbol
- STAT5A
- Aliases
- MGF; STAT5
- Common name
- signal transducer and activator of transcription 5A
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Like STAT5B, STAT5A is an important player in the activation of transcription and intracellular signalling. Mice with disrupted STAT5A and STAT5B, though short-lived due to numerous other deficiencies, exhibit phenotypes similar to those observed in GHR knockout mice in that they are 20%-40% smaller than controls with signs of disrupted GH1 functions such as lower IGF1 levels [1892]. Absence of Stat5 from pancreatic beta-cells in mice has no discernable impact on islet development and function in young animals, however, Stat5 appears to be an important component in beta-cell function in older mice [3666]. Its relation to other proteins that may be involved in ageing make STAT5A a promising subject of research in gerontology [266], though it is not known whether it plays a role in human ageing.
Cytogenetic information
- Cytogenetic band
- 17q11.2
- Location
- 42,287,547 bp to 42,311,942 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000255; allantoin metabolic process
GO:0001938; positive regulation of endothelial cell proliferation
GO:0006101; citrate metabolic process
GO:0006103; 2-oxoglutarate metabolic process
GO:0006105; succinate metabolic process
GO:0006107; oxaloacetate metabolic process
GO:0006351; transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006549; isoleucine metabolic process
GO:0006573; valine metabolic process
GO:0006600; creatine metabolic process
And 11 more GO terms Cellular component: GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0004713; protein tyrosine kinase activity
GO:0004871; signal transducer activity
GO:0005515; protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- GHR, SHC1, PTPN11, STAT5A, PTPN1, EGFR, INSR, PDGFRB, EPOR, BRCA1, BRCA2, NFKB1, EP300, HDAC1, JAK2, ESR1, PPARG, SQSTM1
- STRING interaction network
Retrieve sequences for STAT5A
Homologs in model organisms
- Caenorhabditis elegans
- sta-1
- Danio rerio
- stat5a
- Danio rerio
- stat5b
- Drosophila melanogaster
- Stat92E
- Mus musculus
- Stat5a
- Rattus norvegicus
- Stat5a
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Stat92E
- CellAge
- This gene is present as STAT5A
Selected references
External links
- EPD
- ORF Accession
- NM_003152
- CDS Accession
- NP_003143
- OMIM
- 601511
- HPRD
- 03301
- Ensembl
- STAT5A
- UniProt/Swiss-Prot
- STA5A_HUMAN
- GeneCards
- STAT5A
- Entrez Gene
- 6776
- GenAtlas
- STAT5A
- Internet
- Search Google