GenAge entry for PPARG (Homo sapiens)

Gene name (HAGRID: 263)

HGNC symbol: PPARG
Aliases: PPARG1; PPARG2; NR1C3; PPARgamma
Common name: peroxisome proliferator-activated receptor gamma

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing

Description

Peroxisome proliferator-activated receptor (PPAR)gamma-2 is an important regulator of adipose tissue metabolism, insulin sensitivity and inflammatory response. Recent studies have identified klotho (KL) as a target gene for peroxisome proliferator-activated receptor-gamma (PPARg) [2141]. Mutant mice with a lowered expression of Pparg had a reduced lifespan compared to wild type [2142], however adipose tissue-specific PPARg heterozygous mice exhibited significant improvement in insulin sensitivity in skeletal muscle and showed an increased resistance to paraquat-induced oxidative stress [3665]. The level of PPARs (including PPARG) is reduced with age and caloric restriction in mice appears to prevent these alteration, suggesting common mechanisms [2143].

Mutations in PPARG may be one of the causes of type 2 insulin-resistant diabetes and hyptertension [2144] and a polymorphism of PPARG has been associated to early atherosclerosis [2145]. Defects in PPARG may also be associated with colon cancer [2146]. Genome-wide association studies have identified a paraoxonase Pro/Ala gene polyporphism which is associated to human longevity [2147].

Cytogenetic information

Cytogenetic band: 3p25
Location: 12,287,850 bp to 12,434,356 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001890; placenta development
GO:0002674; negative regulation of acute inflammatory response
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006629; lipid metabolic process
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165; signal transduction
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007507; heart development
GO:0007584; response to nutrient
GO:0008217; regulation of blood pressure

And 56 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005794; Golgi apparatus
GO:0005829; cytosol
GO:0043231; intracellular membrane-bounded organelle
GO:0048471; perinuclear region of cytoplasm
GO:0090575; RNA polymerase II transcription factor complex

Function:

GO:0001046; core promoter sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003707; steroid hormone receptor activity
GO:0004879; RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0004955; prostaglandin receptor activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0008144; drug binding
GO:0008270; zinc ion binding

And 12 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: POU1F1, STAT5A, HDAC3, EGFR, NCOR1, JUND, PIN1, CREBBP, IGFBP3, NR3C1, NFKB1, UBE2I, CEBPB, EP300, PML, PRKCA, XRCC5, XRCC6, RB1, APP, RELA, HDAC1, SP1, JUN, MED1, TFAP2A, MDM2, CTNNB1, PPARGC1A, PPARG, NCOR2, IKBKB
STRING interaction network

Retrieve sequences for PPARG

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: sex-1
Caenorhabditis elegans: nhr-38
Danio rerio: pparg
Mus musculus: Pparg
Rattus norvegicus: Pparg

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Pparg

LongevityMap

This gene is present as PPARG

CellAge

This gene is present as PPARG