GenAge entry for STAT5B (Homo sapiens)
Gene name (HAGRID: 21)
- HGNC symbol
- STAT5B
- Aliases
- Common name
- signal transducer and activator of transcription 5B
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
STAT5B is an important player in the activation of transcription and intracellular signalling. Mice with disrupted STAT5B and STAT5A, though short-lived due to numerous other deficiencies, exhibit phenotypes similar to those observed in GHR knockout mice in that they are 20%-40% smaller than controls with signs of disrupted GH1 functions such as lower IGF1 levels [1892]. Absence of Stat5 from pancreatic beta-cells in mice has no discernable impact on islet development and function in young animals, however, Stat5 appears to be an important component in beta-cell function in older mice [3666]. Its relation to other proteins that may be involved in ageing make STAT5B a possible, albeit unproven, player in human ageing and age-related disease [266].
Cytogenetic information
- Cytogenetic band
- 17q11.2
- Location
- 42,199,177 bp to 42,276,406 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000255; allantoin metabolic process
GO:0001553; luteinization
GO:0001779; natural killer cell differentiation
GO:0006101; citrate metabolic process
GO:0006103; 2-oxoglutarate metabolic process
GO:0006105; succinate metabolic process
GO:0006107; oxaloacetate metabolic process
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0006549; isoleucine metabolic process
GO:0006573; valine metabolic process
And 43 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0004713; protein tyrosine kinase activity
GO:0004871; signal transducer activity
GO:0005515; protein binding
GO:0019903; protein phosphatase binding
GO:0035259; glucocorticoid receptor binding
GO:0046983; protein dimerization activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- GHR, SHC1, PTPN11, STAT5B, STAT3, PTPN1, EGFR, INSR, NR3C1, APP, JAK2
- STRING interaction network
Retrieve sequences for STAT5B
Homologs in model organisms
- Caenorhabditis elegans
- sta-1
- Danio rerio
- stat5a
- Danio rerio
- stat5b
- Drosophila melanogaster
- Stat92E
- Mus musculus
- Stat5b
- Rattus norvegicus
- Stat5b
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as Stat92E
- CellAge
- This gene is present as STAT5B
Selected references
External links
- EPD
- ORF Accession
- NM_012448
- CDS Accession
- NP_036580
- OMIM
- 604260
- HPRD
- 05037
- Ensembl
- STAT5B
- UniProt/Swiss-Prot
- STA5B_HUMAN
- GeneCards
- STAT5B
- Entrez Gene
- 6777
- GenAtlas
- STAT5B
- Internet
- Search Google