GenAge entry for STAT5B (Homo sapiens)

Gene name (HAGRID: 21)

HGNC symbol
STAT5B 
Aliases
 
Common name
signal transducer and activator of transcription 5B 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

STAT5B is an important player in the activation of transcription and intracellular signalling. Mice with disrupted STAT5B and STAT5A, though short-lived due to numerous other deficiencies, exhibit phenotypes similar to those observed in GHR knockout mice in that they are 20%-40% smaller than controls with signs of disrupted GH1 functions such as lower IGF1 levels [1892]. Absence of Stat5 from pancreatic beta-cells in mice has no discernable impact on islet development and function in young animals, however, Stat5 appears to be an important component in beta-cell function in older mice [3666]. Its relation to other proteins that may be involved in ageing make STAT5B a possible, albeit unproven, player in human ageing and age-related disease [266].

Cytogenetic information

Cytogenetic band
17q11.2
Location
42,199,177 bp to 42,276,406 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000255; allantoin metabolic process
GO:0001553; luteinization
GO:0001779; natural killer cell differentiation
GO:0006101; citrate metabolic process
GO:0006103; 2-oxoglutarate metabolic process
GO:0006105; succinate metabolic process
GO:0006107; oxaloacetate metabolic process
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006366; transcription from RNA polymerase II promoter
GO:0006549; isoleucine metabolic process
GO:0006573; valine metabolic process
And 43 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0004713; protein tyrosine kinase activity
GO:0004871; signal transducer activity
GO:0005515; protein binding
GO:0019903; protein phosphatase binding
GO:0035259; glucocorticoid receptor binding
GO:0046983; protein dimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
GHR, SHC1, PTPN11, STAT5B, STAT3, PTPN1, EGFR, INSR, NR3C1, APP, JAK2
STRING interaction network
Protein-Protein network diagram for STAT5B

Retrieve sequences for STAT5B

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
sta-1
Danio rerio
stat5a
Danio rerio
stat5b
Drosophila melanogaster
Stat92E
Mus musculus
Stat5b
Rattus norvegicus
Stat5b

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Stat92E
CellAge
  • This gene is present as STAT5B

Selected references

External links

EPD
ORF Accession
NM_012448
CDS Accession
NP_036580
OMIM
604260
HPRD
05037
Ensembl
STAT5B
UniProt/Swiss-Prot
STA5B_HUMAN
GeneCards
STAT5B
Entrez Gene
6777
UniGene
632256
GenAtlas
STAT5B
Internet
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