GenAge entry for CREBBP (Homo sapiens)

Gene name (HAGRID: 64)

HGNC symbol
CREBBP 
Aliases
RTS; CBP; KAT3A; RSTS 
Common name
CREB binding protein 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

A transcriptional regulatory protein, CREBBP acetylates histones and mediates cAMP-gene regulation by binding to phosphorylated CREB1. CREBBP null mice die during embryogenesis, but heterozygous animals exhibit lipodystrophy, have increased insulin (INS) and leptin (LEP) sensitivity, and appear to be protected from weight gain induced by a high-fat diet [429]. In humans, defects in CREBBP have been associated with Rubinstein-Taybi syndrome [428]. Its important roles in transcriptional regulation and its large number of interacting partners suggest CREBBP might potentially be involved in some aspects of ageing.

Cytogenetic information

Cytogenetic band
16p13.3
Location
3,725,055 bp to 3,880,120 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001666; response to hypoxia
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0006355; regulation of transcription, DNA-templated
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006461; protein complex assembly
GO:0006473; protein acetylation
GO:0007165; signal transduction
GO:0007219; Notch signaling pathway
GO:0008589; regulation of smoothened signaling pathway
GO:0016032; viral process
And 15 more GO terms
Cellular component: GO:0000123; histone acetyltransferase complex
GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0016604; nuclear body
Function: GO:0000987; core promoter proximal region sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085; RNA polymerase II transcription factor binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0001105; RNA polymerase II transcription coactivator activity
GO:0001191; transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0002039; p53 binding
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
And 9 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
POU1F1, TP53, WRN, STAT3, AKT1, MYC, FOS, HDAC3, PARP1, BRCA1, CREBBP, HIF1A, NCOR1, EGR1, UBE2I, EP300, PML, HTT, AR, PCNA, XRCC6, FOXO3, FOXO1, HSF1, FOXM1, HDAC1, FGFR1, SP1, JUN, MAPK3, HMGB1, CCNA2, HMGB2, MAP3K5, FOXO4, BMI1, CREB1, ATF2, TBP, HBP1, TFDP1, E2F1, HDAC2, MDM2, DDIT3, RELA, TCF3, SUMO1, HOXB7, NR3C1, CEBPB, ESR1, CTNNB1, ARNTL, CLOCK, PPARGC1A, PPARG, NCOR2, TP73, NFE2L2, CDKN1A, IKBKB
STRING interaction network
Protein-Protein network diagram for CREBBP

Retrieve sequences for CREBBP

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
cbp-2
Caenorhabditis elegans
cbp-1
Caenorhabditis elegans
F40F12.7
Danio rerio
crebbpb
Danio rerio
crebbpa
Drosophila melanogaster
nej
Mus musculus
Crebbp
Rattus norvegicus
Crebbp
Saccharomyces cerevisiae
BDF2
Saccharomyces cerevisiae
BDF1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as CELE_F40F12.7
GenDR gene manipulations
  • A homolog of this gene for Caenorhabditis elegans is present as cbp-1

Selected references

External links

EPD
ORF Accession
NM_004380
CDS Accession
NP_004371
OMIM
600140
HPRD
02534
Ensembl
CREBBP
UniProt/Swiss-Prot
CBP_HUMAN
GeneCards
CREBBP
Entrez Gene
1387
UniGene
459759
GenAtlas
CREBBP
Internet
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