GenAge entry for SUN1 (Homo sapiens)

Gene name (HAGRID: 277)

HGNC symbol
SUN1 
Aliases
KIAA0810; FLJ12407; UNC84A 
Common name
Sad1 and UNC84 domain containing 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

Mutations in the LMNA gene result in Hutchinson-Gilford progeroid syndrome. Two mouse models, Lmna null (Lmna(-/-)) and progeroid Lmna delta9 have been created, displaying these two pathologies, with an accordingly shorten lifespan. In both cases, however, a deficiency in the Sun1 gene resulted in reduced tissue pathologies and enhanced longevity. Similarly, a reduction of SUN1 overaccumulation in LMNA mutant fibroblasts and in cells derived from progeroid patients corrected nuclear defects and cellular senescence [2197]. Further studies are warranted.

Cytogenetic information

Cytogenetic band
7p22.3
Location
816,615 bp to 874,920 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001503; ossification
GO:0006998; nuclear envelope organization
GO:0007129; synapsis
GO:0009612; response to mechanical stimulus
GO:0021817; nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
GO:0051642; centrosome localization
GO:0070197; meiotic attachment of telomere to nuclear envelope
GO:0090286; cytoskeletal anchoring at nuclear membrane
GO:0090292; nuclear matrix anchoring at nuclear membrane
Cellular component: GO:0002080; acrosomal membrane
GO:0005635; nuclear envelope
GO:0005639; integral component of nuclear inner membrane
GO:0031965; nuclear membrane
GO:0034993; LINC complex
GO:0043231; intracellular membrane-bounded organelle
Function: GO:0005515; protein binding
GO:0005521; lamin binding
Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for SUN1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
unc-84
Danio rerio
sun1
Drosophila melanogaster
koi
Mus musculus
Sun1
Rattus norvegicus
Sun1

Selected references

External links

EPD
ORF Accession
NM_001171944
CDS Accession
NP_001165415
OMIM
607723
HPRD
16257
Ensembl
SUN1
UniProt/Swiss-Prot
SUN1_HUMAN
GeneCards
SUN1
Entrez Gene
23353
UniGene
438072
GenAtlas
SUN1
Internet
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