GenAge entry for PRDX1 (Homo sapiens)

Gene name (HAGRID: 141)

HGNC symbol
PRDX1 
Aliases
NKEFA; PAGA 
Common name
peroxiredoxin 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

PRDX1 is involved in redox regulation and possibly in intracellular signalling cascades. Mice lacking PRDX1 have a shorter longevity due to anaemia and cancer, though it is unclear whether these animals age faster [50]. PRDX1 has not been directly associated with human ageing.

Cytogenetic information

Cytogenetic band
1p34.1
Location
45,511,035 bp to 45,521,938 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000302; response to reactive oxygen species
GO:0001501; skeletal system development
GO:0001895; retina homeostasis
GO:0008283; cell proliferation
GO:0019430; removal of superoxide radicals
GO:0032872; regulation of stress-activated MAPK cascade
GO:0034101; erythrocyte homeostasis
GO:0042267; natural killer cell mediated cytotoxicity
GO:0042345; regulation of NF-kappaB import into nucleus
GO:0042744; hydrogen peroxide catabolic process
GO:0045454; cell redox homeostasis
And 3 more GO terms
Cellular component: GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0031012; extracellular matrix
GO:0042470; melanosome
GO:0043209; myelin sheath
GO:0070062; extracellular exosome
Function: GO:0004601; peroxidase activity
GO:0005515; protein binding
GO:0008379; thioredoxin peroxidase activity
GO:0042802; identical protein binding
GO:0044822; poly(A) RNA binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TXN, MYC, EGFR, PTEN, RPA1, ABL1, TERF1, PRKDC, CAT, BAX, SOD1, PRDX1, RAD52, CDC42
STRING interaction network
Protein-Protein network diagram for PRDX1

Retrieve sequences for PRDX1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
prdx-2
Danio rerio
prdx1
Drosophila melanogaster
Jafrac1
Drosophila melanogaster
CG6888
Mus musculus
Prdx1
Rattus norvegicus
Prdx1
Rattus norvegicus
AABR07012795.1
Saccharomyces cerevisiae
TSA1
Saccharomyces cerevisiae
TSA2

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as prdx-2
  • A homolog of this gene for Mus musculus is present as Prdx1
  • A homolog of this gene for Drosophila melanogaster is present as Jafrac1
  • A homolog of this gene for Saccharomyces cerevisiae is present as TSA1
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as TSA1

Selected references

External links

EPD
ORF Accession
NM_181697
CDS Accession
NP_859048
OMIM
176763
HPRD
01458
Ensembl
PRDX1
UniProt/Swiss-Prot
PRDX1_HUMAN
GeneCards
PRDX1
Entrez Gene
5052
UniGene
180909
GenAtlas
PRDX1
Internet
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