GenAge entry for PRDX1 (Homo sapiens)
Gene name (HAGRID: 141)
- HGNC symbol
- PRDX1
- Aliases
- NKEFA; PAGA
- Common name
- peroxiredoxin 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
PRDX1 is involved in redox regulation and possibly in intracellular signalling cascades. Mice lacking PRDX1 have a shorter longevity due to anaemia and cancer, though it is unclear whether these animals age faster [50]. PRDX1 has not been directly associated with human ageing.
Cytogenetic information
- Cytogenetic band
- 1p34.1
- Location
- 45,511,035 bp to 45,521,938 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000302; response to reactive oxygen species
GO:0001501; skeletal system development
GO:0001895; retina homeostasis
GO:0008283; cell proliferation
GO:0019430; removal of superoxide radicals
GO:0032872; regulation of stress-activated MAPK cascade
GO:0034101; erythrocyte homeostasis
GO:0042267; natural killer cell mediated cytotoxicity
GO:0042345; regulation of NF-kappaB import into nucleus
GO:0042744; hydrogen peroxide catabolic process
GO:0045454; cell redox homeostasis
And 3 more GO terms Cellular component: GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0031012; extracellular matrix
GO:0042470; melanosome
GO:0043209; myelin sheath
GO:0070062; extracellular exosome
Function: GO:0004601; peroxidase activity
GO:0005515; protein binding
GO:0008379; thioredoxin peroxidase activity
GO:0042802; identical protein binding
GO:0044822; poly(A) RNA binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Protein interactions and network
- Protein-protein interacting partners in GenAge
- SHC1, TXN, MYC, EGFR, PTEN, RPA1, ABL1, TERF1, PRKDC, CAT, BAX, SOD1, PRDX1, RAD52, CDC42
- STRING interaction network
Retrieve sequences for PRDX1
Homologs in model organisms
- Caenorhabditis elegans
- prdx-2
- Danio rerio
- prdx1
- Drosophila melanogaster
- Jafrac1
- Drosophila melanogaster
- CG6888
- Mus musculus
- Prdx1
- Rattus norvegicus
- Prdx1
- Rattus norvegicus
- AABR07012795.1
- Saccharomyces cerevisiae
- TSA1
- Saccharomyces cerevisiae
- TSA2
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as TSA1
Selected references
External links
- EPD
- ORF Accession
- NM_181697
- CDS Accession
- NP_859048
- OMIM
- 176763
- HPRD
- 01458
- Ensembl
- PRDX1
- UniProt/Swiss-Prot
- PRDX1_HUMAN
- GeneCards
- PRDX1
- Entrez Gene
- 5052
- GenAtlas
- PRDX1
- Internet
- Search Google