GenAge entry for CDKN2B (Homo sapiens)
Gene name (HAGRID: 288)
- HGNC symbol
- CDKN2B
- Aliases
- P15; MTS2; INK4B; TP15; CDK4I; p15INK4b
- Common name
- cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
- Description
The p15 tumor suppressor (CDKN2B) is located in the same region as p16 (CDKN2A), and is also involved in cell cycle, senescence and cancer. This region is frequently mutated and/or deleted in a wide variety of tumors [2229]. Genetic variants have been identified close to both p15 and p16 in patients with type 2 diabetes and cardiovascular disease [2230]. Although CDKN2B seems to have a role in cellular senescence and age-related diseases, its implication in broader aspects of ageing is still unknown.
Cytogenetic information
- Cytogenetic band
- 9p21
- Location
- 22,002,903 bp to 22,009,313 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000079; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086; G2/M transition of mitotic cell cycle
GO:0007050; cell cycle arrest
GO:0007093; mitotic cell cycle checkpoint
GO:0008285; negative regulation of cell proliferation
GO:0030219; megakaryocyte differentiation
GO:0030511; positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031668; cellular response to extracellular stimulus
GO:0031670; cellular response to nutrient
GO:0042326; negative regulation of phosphorylation
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
And 5 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
Function: GO:0004861; cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515; protein binding
GO:0019901; protein kinase binding
Protein interactions and network
Retrieve sequences for CDKN2B
Homologs in model organisms
In other databases
- LongevityMap
- This gene is present as CDKN2B
- CellAge
- This gene is present as CDKN2B
- CellAge gene expression
- This gene is present as CDKN2B
Selected references
External links
- EPD
- ORF Accession
- NM_004936
- CDS Accession
- NP_004927
- OMIM
- 600431
- HPRD
- 02696
- Ensembl
- CDKN2B
- UniProt/Swiss-Prot
- CDN2B_HUMAN
- GeneCards
- CDKN2B
- Entrez Gene
- 1030
- GenAtlas
- CDKN2B
- Internet
- Search Google