GenAge entry for LRP2 (Homo sapiens)

Gene name (HAGRID: 134)

HGNC symbol
LRP2 
Aliases
gp330; DBS 
Common name
low density lipoprotein receptor-related protein 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

LRP2 binds CLU and other ligands and may play a role in cholesterol homeostasis. It may also help regulate the release of parathyroid hormone [684]. Disruption of LRP2 in mice results in defective forebrain development [683]. Its role, if any, in human ageing is unclear.

Cytogenetic information

Cytogenetic band
2q31.1
Location
169,127,109 bp to 169,362,612 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001523; retinoid metabolic process
GO:0003281; ventricular septum development
GO:0006486; protein glycosylation
GO:0006629; lipid metabolic process
GO:0006897; endocytosis
GO:0006898; receptor-mediated endocytosis
GO:0008283; cell proliferation
GO:0030900; forebrain development
GO:0035904; aorta development
GO:0042359; vitamin D metabolic process
GO:0042953; lipoprotein transport
And 2 more GO terms
Cellular component: GO:0005764; lysosome
GO:0005765; lysosomal membrane
GO:0005768; endosome
GO:0005783; endoplasmic reticulum
GO:0005794; Golgi apparatus
GO:0005886; plasma membrane
GO:0005905; clathrin-coated pit
GO:0016021; integral component of membrane
GO:0016324; apical plasma membrane
GO:0030139; endocytic vesicle
GO:0031526; brush border membrane
And 3 more GO terms
Function: GO:0005041; low-density lipoprotein receptor activity
GO:0005509; calcium ion binding
GO:0005515; protein binding
GO:0017124; SH3 domain binding
GO:0042954; lipoprotein transporter activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PLAU, APP, APOE, CLU
STRING interaction network
Protein-Protein network diagram for LRP2

Retrieve sequences for LRP2

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
lrp-1
Danio rerio
lrp2a
Drosophila melanogaster
mgl
Mus musculus
Lrp2
Rattus norvegicus
Lrp2

Selected references

External links

EPD
ORF Accession
NM_004525
CDS Accession
NP_004516
OMIM
600073
HPRD
02509
Ensembl
LRP2
UniProt/Swiss-Prot
LRP2_HUMAN
GeneCards
LRP2
Entrez Gene
4036
GenAtlas
LRP2
Internet
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