GenAge entry for LRP2 (Homo sapiens)
Gene name (HAGRID: 134)
- HGNC symbol
- LRP2
- Aliases
- gp330; DBS
- Common name
- low density lipoprotein receptor-related protein 2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
LRP2 binds CLU and other ligands and may play a role in cholesterol homeostasis. It may also help regulate the release of parathyroid hormone [684]. Disruption of LRP2 in mice results in defective forebrain development [683]. Its role, if any, in human ageing is unclear.
Cytogenetic information
- Cytogenetic band
- 2q31.1
- Location
- 169,127,109 bp to 169,362,612 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0001523; retinoid metabolic process
GO:0003281; ventricular septum development
GO:0006486; protein glycosylation
GO:0006629; lipid metabolic process
GO:0006897; endocytosis
GO:0006898; receptor-mediated endocytosis
GO:0008283; cell proliferation
GO:0030900; forebrain development
GO:0035904; aorta development
GO:0042359; vitamin D metabolic process
GO:0042953; lipoprotein transport
And 2 more GO terms Cellular component: GO:0005764; lysosome
GO:0005765; lysosomal membrane
GO:0005768; endosome
GO:0005783; endoplasmic reticulum
GO:0005794; Golgi apparatus
GO:0005886; plasma membrane
GO:0005905; clathrin-coated pit
GO:0016021; integral component of membrane
GO:0016324; apical plasma membrane
GO:0030139; endocytic vesicle
GO:0031526; brush border membrane
And 3 more GO terms Function: GO:0005041; low-density lipoprotein receptor activity
GO:0005509; calcium ion binding
GO:0005515; protein binding
GO:0017124; SH3 domain binding
GO:0042954; lipoprotein transporter activity
Protein interactions and network
Retrieve sequences for LRP2
Homologs in model organisms
- Caenorhabditis elegans
- lrp-1
- Danio rerio
- lrp2a
- Drosophila melanogaster
- mgl
- Mus musculus
- Lrp2
- Rattus norvegicus
- Lrp2
Selected references
External links
- EPD
- ORF Accession
- NM_004525
- CDS Accession
- NP_004516
- OMIM
- 600073
- HPRD
- 02509
- Ensembl
- LRP2
- UniProt/Swiss-Prot
- LRP2_HUMAN
- GeneCards
- LRP2
- Entrez Gene
- 4036
- GenAtlas
- LRP2
- Internet
- Search Google