GenAge entry for MAPT (Homo sapiens)

Gene name (HAGRID: 205)

HGNC symbol
MAPT 
Aliases
MTBT1; tau; PPND; FTDP-17; TAU; MSTD; MTBT2; FLJ31424; MGC138549; PPP1R103; DDPAC; MAPTL 
Common name
microtubule-associated protein tau 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

The MAPT protein appears to promote microtubule assembly and stability. MAPT undergoes complex alternative splicing and its transcripts are differentially expressed in the nervous system depending on neuron type and maturation. Abundant evidence exists linking mutations in MAPT to neurodegenerative diseases in humans [1429].

Cytogenetic information

Cytogenetic band
17q21.1
Location
45,894,382 bp to 46,028,333 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000226; microtubule cytoskeleton organization
GO:0001774; microglial cell activation
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165; signal transduction
GO:0007613; memory
GO:0010506; regulation of autophagy
GO:0010917; negative regulation of mitochondrial membrane potential
GO:0019896; axonal transport of mitochondrion
GO:0031113; regulation of microtubule polymerization
GO:0031116; positive regulation of microtubule polymerization
GO:0031122; cytoplasmic microtubule organization
And 23 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005829; cytosol
GO:0005874; microtubule
GO:0005886; plasma membrane
GO:0016020; membrane
GO:0030424; axon
GO:0030425; dendrite
GO:0030426; growth cone
GO:0034399; nuclear periphery
GO:0036464; cytoplasmic ribonucleoprotein granule
GO:0036477; somatodendritic compartment
And 6 more GO terms
Function: GO:0003677; DNA binding
GO:0003779; actin binding
GO:0005515; protein binding
GO:0008017; microtubule binding
GO:0017124; SH3 domain binding
GO:0019899; enzyme binding
GO:0034185; apolipoprotein binding
GO:0034452; dynactin binding
GO:0048018; receptor agonist activity
GO:0051721; protein phosphatase 2A binding
GO:0051879; Hsp90 protein binding
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
AKT1, EGFR, PIN1, S100B, ABL1, EP300, GSK3B, APP, APOE, SIRT1, HSPA1A, MAPK8, YWHAZ, PTK2B, HSPA8, MAPT, PSEN1, STUB1, GSK3A, SQSTM1
STRING interaction network
Protein-Protein network diagram for MAPT

Retrieve sequences for MAPT

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
ptl-1
Danio rerio
maptb
Danio rerio
mapta
Drosophila melanogaster
tau
Mus musculus
Mapt
Rattus norvegicus
Mapt

Selected references

External links

EPD
ORF Accession
NM_016835
CDS Accession
NP_058519
OMIM
157140
HPRD
01142
Ensembl
MAPT
UniProt/Swiss-Prot
TAU_HUMAN
GeneCards
MAPT
Entrez Gene
4137
UniGene
101174
GenAtlas
MAPT
Internet
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