GenAge entry for UCP3 (Homo sapiens)

Gene name (HAGRID: 232)

HGNC symbol
UCP3 
Aliases
SLC25A9 
Common name
uncoupling protein 3 (mitochondrial, proton carrier) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis resulting in energy being dissipated as heat. UCP3, whose gene has two splice variants, appears thus to be involved in thermogenesis. Some results from mice suggest that UCP3 might protect against oxidative damage [1449]. Mice overexpressing UCP3 in skeletal muscle are hyperphagic and lean [1456]. UCP3-null mice were normal, though production of reactive oxygen species was increased in mitochondria [1458]. Polymorphisms in the human UCP3 gene could be related to obesity and type 2 diabetes [1459].

Cytogenetic information

Cytogenetic band
11q13.4
Location
74,000,281 bp to 74,009,237 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000303; response to superoxide
GO:0001666; response to hypoxia
GO:0006629; lipid metabolic process
GO:0006631; fatty acid metabolic process
GO:0006839; mitochondrial transport
GO:0007568; aging
GO:0007584; response to nutrient
GO:0007585; respiratory gaseous exchange
GO:0009409; response to cold
GO:0014823; response to activity
GO:0015992; proton transport
And 4 more GO terms
Cellular component: GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0016021; integral component of membrane
Function: GO:0005215; transporter activity
GO:0005515; protein binding
GO:0017077; oxidative phosphorylation uncoupler activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
YWHAZ
STRING interaction network
Protein-Protein network diagram for UCP3

Retrieve sequences for UCP3

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
ucp3
Mus musculus
Ucp3
Rattus norvegicus
Ucp3
Saccharomyces cerevisiae
DIC1

In other databases

LongevityMap
  • This gene is present as UCP3

Selected references

External links

EPD
ORF Accession
NM_003356
CDS Accession
NP_003347
OMIM
602044
HPRD
03623
Ensembl
UCP3
UniProt/Swiss-Prot
UCP3_HUMAN
GeneCards
UCP3
Entrez Gene
7352
UniGene
101337
GenAtlas
UCP3
Internet
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