GenAge entry for EEF2 (Homo sapiens)
Gene name (HAGRID: 103)
- HGNC symbol
- EEF2
- Aliases
- EEF-2; EF2
- Common name
- eukaryotic translation elongation factor 2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
EEF2 is involved in protein synthesis. Age-dependent changes to EEF2 in rats have been reported, which could account for the decline in protein synthesis in old animals [540]. EEF2 has not been directly related to human ageing.
Cytogenetic information
- Cytogenetic band
- 19p13.3
- Location
- 3,976,056 bp to 3,985,463 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0002244; hematopoietic progenitor cell differentiation
GO:0002931; response to ischemia
GO:0003009; skeletal muscle contraction
GO:0006414; translational elongation
GO:0007568; aging
GO:0014009; glial cell proliferation
GO:0017183; peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0032355; response to estradiol
GO:0034976; response to endoplasmic reticulum stress
GO:0035914; skeletal muscle cell differentiation
GO:0042493; response to drug
And 8 more GO terms Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005913; cell-cell adherens junction
GO:0016020; membrane
GO:0016235; aggresome
GO:0030529; intracellular ribonucleoprotein complex
GO:0031012; extracellular matrix
GO:0042788; polysomal ribosome
GO:0045121; membrane raft
And 2 more GO terms Function: GO:0002039; p53 binding
GO:0003746; translation elongation factor activity
GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0005525; GTP binding
GO:0008097; 5S rRNA binding
GO:0019901; protein kinase binding
GO:0043022; ribosome binding
GO:0044822; poly(A) RNA binding
GO:0051015; actin filament binding
GO:0098641; cadherin binding involved in cell-cell adhesion
And 1 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, TXN, PTEN, HSP90AA1, EP300, XRCC6, GSR, HSPD1, MAPK14, EEF1A1, ATF2, BUB1B, HSPA8, MDM2, ESR1, CDKN2A, SIRT6, MLH1
- STRING interaction network
Retrieve sequences for EEF2
Homologs in model organisms
- Caenorhabditis elegans
- eef-2
- Danio rerio
- eef2l2
- Drosophila melanogaster
- EF2
- Mus musculus
- Eef2
- Rattus norvegicus
- Eef2
- Saccharomyces cerevisiae
- EFT1
- Saccharomyces cerevisiae
- EFT1
- Schizosaccharomyces pombe
- eft201
In other databases
- GenAge model organism genes