GenAge entry for IFNB1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 308)

HGNC symbol
IFNB1 
Aliases
IFB; IFF; IFNB; IFN-beta 
Common name
Interferon beta 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

IFNB1 is a cytokine signalling protein that belongs to the interferon family (IFN), which acts as part of the innate immune response. IFNB1 is a type I IFN and normally exerts antiproliferative, antiangiogenic, proapoptotic and immunemodulatory functions [4330].

IFNB1 has been shown to be part of the DNA damage response, a process involved in human ageing [4331]. In Terc knockout mice, which normally show accelerated ageing, inactivation of IFNB1 results in the abrogation of progeric phenotypes and extends lifespan. In human and mouse cells the accumulation of DNA damage results in the production of IFNB1 and triggers IFN signalling both in vitro and in vivo [4331]. In addition, inhibition of IFNB1 leads to decreased cell senescence, demonstrating that IFNB1 is a mediator of cell senescence [4331]. Thus, IFN signalling may act as a mechanism that links DNA damage to senescence and premature ageing.

Cytogenetic information

Cytogenetic band
9p21.3
Location
21,077,104 bp to 21,077,962 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002250; adaptive immune response
GO:0002286; T cell activation involved in immune response
GO:0002312; B cell activation involved in immune response
GO:0002323; natural killer cell activation involved in immune response
GO:0006959; humoral immune response
GO:0007166; cell surface receptor signaling pathway
GO:0007596; blood coagulation
GO:0009615; response to virus
GO:0030101; natural killer cell activation
GO:0030183; B cell differentiation
GO:0033141; positive regulation of peptidyl-serine phosphorylation of STAT protein
And 18 more GO terms
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
Function: GO:0005125; cytokine activity
GO:0005132; type I interferon receptor binding
GO:0008811; chloramphenicol O-acetyltransferase activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
IFNB1
STRING interaction network
Protein-Protein network diagram for IFNB1

Retrieve sequences for IFNB1

ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Ifnb1
Rattus norvegicus
Ifnb1

Selected references

External links

EPD
ORF Accession
NM_002176
CDS Accession
NP_002167
OMIM
147640
HPRD
Ensembl
IFNB1
UniProt/Swiss-Prot
IFNB_HUMAN
GeneCards
IFNB1
Entrez Gene
3456
GenAtlas
IFNB1
Internet
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