GenAge entry for CDC42 (Homo sapiens)

Gene name (HAGRID: 250)

HGNC symbol
CDC42 
Aliases
G25K; CDC42Hs 
Common name
cell division cycle 42 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

CDC42 is regulates numerous signalling pathways, including cell cycle progression. Its activity increases with age in various mouse tissues. In mice, gene targeting of ARHGAP1, a negative regulator of CDC42, results in elevated levels of CDC42. The animals display multiple premature ageing-like phenotypes, suggesting this gene may play a role in mammalian ageing. CDC42 activation promotes a premature cellular senescence phenotype dependent on TP53 [1840].

Cytogenetic information

Cytogenetic band
1p36.1
Location
22,052,627 bp to 22,092,943 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002040; sprouting angiogenesis
GO:0003161; cardiac conduction system development
GO:0003334; keratinocyte development
GO:0007030; Golgi organization
GO:0007088; regulation of mitotic nuclear division
GO:0007097; nuclear migration
GO:0007163; establishment or maintenance of cell polarity
GO:0007264; small GTPase mediated signal transduction
GO:0007596; blood coagulation
GO:0010628; positive regulation of gene expression
GO:0010629; negative regulation of gene expression
And 53 more GO terms
Cellular component: GO:0000139; Golgi membrane
GO:0000322; storage vacuole
GO:0005737; cytoplasm
GO:0005789; endoplasmic reticulum membrane
GO:0005815; microtubule organizing center
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0005925; focal adhesion
GO:0016020; membrane
GO:0030141; secretory granule
And 12 more GO terms
Function: GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0005525; GTP binding
GO:0019901; protein kinase binding
GO:0030742; GTP-dependent protein binding
GO:0031435; mitogen-activated protein kinase kinase kinase binding
GO:0031996; thioesterase binding
GO:0034191; apolipoprotein A-I receptor binding
GO:0042802; identical protein binding
GO:0051022; Rho GDP-dissociation inhibitor binding
GO:0061630; ubiquitin protein ligase activity
And 1 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, RAD51, TNF, ERCC3, GRB2, A2M, PRDX1, MT-CO1, MAPK8, MAPK9, DBN1, ARHGAP1, CDC42
STRING interaction network
Protein-Protein network diagram for CDC42

Retrieve sequences for CDC42

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
cdc42
Drosophila melanogaster
Cdc42
Mus musculus
Cdc42
Rattus norvegicus
Cdc42
Saccharomyces cerevisiae
CDC42
Schizosaccharomyces pombe
cdc42

Selected references

External links

EPD
ORF Accession
NM_001791
CDS Accession
NP_001782
OMIM
116952
HPRD
00309
Ensembl
CDC42
UniProt/Swiss-Prot
CDC42_HUMAN
GeneCards
CDC42
Entrez Gene
998
UniGene
690198
GenAtlas
CDC42
Internet
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