GenAge entry for PCMT1 (Homo sapiens)

Gene name (HAGRID: 162)

HGNC symbol
PCMT1 
Aliases
 
Common name
protein-L-isoaspartate (D-aspartate) O-methyltransferase 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

PCMT1 is involved in the repair and degradation of damaged proteins. Overexpression of a PCMT1 homologue in fruit flies extends lifespan in a temperature-dependent fashion [211]. PCMT1-deficient mice die at about 42 days after birth, though without signs of premature ageing [760]. Although an age-related accumulation of defective proteins has been suggested as a factor in ageing, further research is needed to assess PCMT1's role, if any, in mammalian ageing.

Cytogenetic information

Cytogenetic band
6q24-q25
Location
149,749,695 bp to 149,811,421 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006479; protein methylation
GO:0030091; protein repair
GO:0098609; cell-cell adhesion
Cellular component: GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005913; cell-cell adherens junction
GO:0070062; extracellular exosome
GO:1903561; extracellular vesicle
Function: GO:0004719; protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
GO:0005515; protein binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, LMNA, TERF1, TERF2, SOD1, APOE, CSNK1E, TP53BP1, MIF, TRAP1
STRING interaction network
Protein-Protein network diagram for PCMT1

Retrieve sequences for PCMT1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
pcm-1
Danio rerio
pcmt
Drosophila melanogaster
Pcmt
Mus musculus
Pcmt1
Rattus norvegicus
Pcmt1
Schizosaccharomyces pombe
pcm2

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Pcmt
  • A homolog of this gene for Caenorhabditis elegans is present as pcm-1

Selected references

External links

EPD
ORF Accession
NM_005389
CDS Accession
NP_005380
OMIM
176851
HPRD
08908
Ensembl
PCMT1
UniProt/Swiss-Prot
PIMT_HUMAN
GeneCards
PCMT1
Entrez Gene
5110
GenAtlas
PCMT1
Internet
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