GenAge entry for MAPK14 (Homo sapiens)
Gene name (HAGRID: 168)
- HGNC symbol
- MAPK14
- Aliases
- PRKM14; p38; Mxi2; PRKM15; CSPB1; CSBP1; CSBP2
- Common name
- mitogen-activated protein kinase 14
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
- Description
Also known as p38, MAPK14 is activated in response to cellular stress and it can phosphorylate a number of transcription factors. It is also involved in the production of IL6 [137], and is an important player in cellular senescence [140]. In-vitro inhibition of p38 enhances the proliferative potential of mice muscle stem cells and restores the age-declined regenerative potential of stem cells populations [3640]. In senescent CD8+ T cells its inhibition increases proliferation, telomerase activity, mitochondrial biogenesis, and fitness, in a mTOR-independent manner [3641]. Mice without MAPK14 are anaemic due to failed definitive erythropoiesis [773]. Transgenic mice with induced MAPK14 activity in the heart died in 7-9 weeks [775]. MAPK14's responsiveness may change with ageing in mouse cells [176]. A role for MAPK14 in human ageing is so far unknown.
Cytogenetic information
- Cytogenetic band
- 6p21
- Location
- 36,027,677 bp to 36,111,236 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000077; DNA damage checkpoint
GO:0000187; activation of MAPK activity
GO:0000902; cell morphogenesis
GO:0001502; cartilage condensation
GO:0001525; angiogenesis
GO:0001890; placenta development
GO:0002062; chondrocyte differentiation
GO:0006006; glucose metabolic process
GO:0006351; transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006915; apoptotic process
And 46 more GO terms Cellular component: GO:0000922; spindle pole
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0070062; extracellular exosome
Function: GO:0004674; protein serine/threonine kinase activity
GO:0004707; MAP kinase activity
GO:0004708; MAP kinase kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019899; enzyme binding
GO:0019903; protein phosphatase binding
GO:0051525; NFAT protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, ATM, PTPN11, HDAC3, AKT1, EGFR, EP300, EEF2, RB1, RECQL4, RELA, HDAC1, HSPD1, MAPK14, SP1, JUN, MAPK3, BMI1, EEF1A1, CREB1, ATF2, DDIT3, MAX, NFKBIA, HTRA2, IKBKB, SQSTM1, RICTOR
- STRING interaction network
Retrieve sequences for MAPK14
Homologs in model organisms
- Caenorhabditis elegans
- pmk-2
- Caenorhabditis elegans
- pmk-1
- Danio rerio
- mapk14b
- Danio rerio
- mapk14a
- Drosophila melanogaster
- p38b
- Drosophila melanogaster
- p38a
- Drosophila melanogaster
- p38c
- Mus musculus
- Mapk14
- Rattus norvegicus
- Mapk14
- Saccharomyces cerevisiae
- HOG1
In other databases
- GenAge model organism genes
- CellAge
- This gene is present as MAPK14
Selected references
External links
- EPD
- ORF Accession
- NM_001315
- CDS Accession
- NP_001306
- OMIM
- 600289
- HPRD
- 02619
- Ensembl
- MAPK14
- UniProt/Swiss-Prot
- MK14_HUMAN
- GeneCards
- MAPK14
- Entrez Gene
- 1432
- GenAtlas
- MAPK14
- Internet
- Search Google