GenAge entry for MAPK14 (Homo sapiens)

Gene name (HAGRID: 168)

HGNC symbol
MAPK14 
Aliases
PRKM14; p38; Mxi2; PRKM15; CSPB1; CSBP1; CSBP2 
Common name
mitogen-activated protein kinase 14 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

Also known as p38, MAPK14 is activated in response to cellular stress and it can phosphorylate a number of transcription factors. It is also involved in the production of IL6 [137], and is an important player in cellular senescence [140]. In-vitro inhibition of p38 enhances the proliferative potential of mice muscle stem cells and restores the age-declined regenerative potential of stem cells populations [3640]. In senescent CD8+ T cells its inhibition increases proliferation, telomerase activity, mitochondrial biogenesis, and fitness, in a mTOR-independent manner [3641]. Mice without MAPK14 are anaemic due to failed definitive erythropoiesis [773]. Transgenic mice with induced MAPK14 activity in the heart died in 7-9 weeks [775]. MAPK14's responsiveness may change with ageing in mouse cells [176]. A role for MAPK14 in human ageing is so far unknown.

Cytogenetic information

Cytogenetic band
6p21
Location
36,027,677 bp to 36,111,236 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000077; DNA damage checkpoint
GO:0000187; activation of MAPK activity
GO:0000902; cell morphogenesis
GO:0001502; cartilage condensation
GO:0001525; angiogenesis
GO:0001890; placenta development
GO:0002062; chondrocyte differentiation
GO:0006006; glucose metabolic process
GO:0006351; transcription, DNA-templated
GO:0006357; regulation of transcription from RNA polymerase II promoter
GO:0006915; apoptotic process
And 46 more GO terms
Cellular component: GO:0000922; spindle pole
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0070062; extracellular exosome
Function: GO:0004674; protein serine/threonine kinase activity
GO:0004707; MAP kinase activity
GO:0004708; MAP kinase kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019899; enzyme binding
GO:0019903; protein phosphatase binding
GO:0051525; NFAT protein binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, PTPN11, HDAC3, AKT1, EGFR, EP300, EEF2, RB1, RECQL4, RELA, HDAC1, HSPD1, MAPK14, SP1, JUN, MAPK3, BMI1, EEF1A1, CREB1, ATF2, DDIT3, MAX, NFKBIA, HTRA2, IKBKB, SQSTM1, RICTOR
STRING interaction network
Protein-Protein network diagram for MAPK14

Retrieve sequences for MAPK14

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
pmk-2
Caenorhabditis elegans
pmk-1
Danio rerio
mapk14b
Danio rerio
mapk14a
Drosophila melanogaster
p38b
Drosophila melanogaster
p38a
Drosophila melanogaster
p38c
Mus musculus
Mapk14
Rattus norvegicus
Mapk14
Saccharomyces cerevisiae
HOG1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as p38b
  • A homolog of this gene for Drosophila melanogaster is present as Mpk2
CellAge
  • This gene is present as MAPK14

Selected references

External links

EPD
ORF Accession
NM_001315
CDS Accession
NP_001306
OMIM
600289
HPRD
02619
Ensembl
MAPK14
UniProt/Swiss-Prot
MK14_HUMAN
GeneCards
MAPK14
Entrez Gene
1432
UniGene
485233
GenAtlas
MAPK14
Internet
Search Google