GenAge entry for GSK3B (Homo sapiens)
Gene name (HAGRID: 97)
- HGNC symbol
- GSK3B
- Aliases
- Common name
- glycogen synthase kinase 3 beta
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
Involved in development and metabolism, GSK3B may also play a role in cell survival. GSK3B null mice die at embryonic stages [522]. Adult overexpression of GSK3B in the brain of mice resulted in neurodegeneration, suggesting GSK3B could be related to Alzheimer's disease [1682]. Its part in human ageing, if any, is unknown.
Cytogenetic information
- Cytogenetic band
- 3q13.3
- Location
- 119,821,955 bp to 120,094,417 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000320; re-entry into mitotic cell cycle
GO:0001837; epithelial to mesenchymal transition
GO:0001954; positive regulation of cell-matrix adhesion
GO:0005977; glycogen metabolic process
GO:0006349; regulation of gene expression by genetic imprinting
GO:0006468; protein phosphorylation
GO:0006611; protein export from nucleus
GO:0006983; ER overload response
GO:0007212; dopamine receptor signaling pathway
GO:0007409; axonogenesis
GO:0007520; myoblast fusion
And 54 more GO terms Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005813; centrosome
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0014069; postsynaptic density
GO:0030426; growth cone
GO:0030529; intracellular ribonucleoprotein complex
GO:0030877; beta-catenin destruction complex
GO:0043025; neuronal cell body
And 4 more GO terms Function: GO:0001085; RNA polymerase II transcription factor binding
GO:0002020; protease binding
GO:0002039; p53 binding
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008013; beta-catenin binding
GO:0016301; kinase activity
GO:0019901; protein kinase binding
GO:0031625; ubiquitin protein ligase binding
And 4 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, E2F1, PTPN11, PTPN1, AKT1, MYC, HSP90AA1, TOP2A, NFKB1, CEBPB, STK11, GSK3B, PRKCA, PRKDC, AR, FEN1, FOXO1, FOXM1, APP, RELA, PTK2, JUN, EEF1A1, CREB1, MAPT, MDM2, MTOR, CTNNB1, PSEN1, PPP1CA, PPARGC1A, NFE2L2, RICTOR, NFE2L1
- STRING interaction network
Retrieve sequences for GSK3B
Homologs in model organisms
- Caenorhabditis elegans
- gsk-3
- Danio rerio
- GSK3B (1 of many)
- Danio rerio
- gsk3b
- Drosophila melanogaster
- sgg
- Mus musculus
- Gsk3b
- Rattus norvegicus
- Gsk3b
- Saccharomyces cerevisiae
- RIM11
- Saccharomyces cerevisiae
- MRK1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as RIM11
- CellAge
- This gene is present as GSK3B
Selected references
External links
- EPD
- ORF Accession
- NM_002093
- CDS Accession
- NP_002084
- OMIM
- 605004
- HPRD
- 05418
- Ensembl
- GSK3B
- UniProt/Swiss-Prot
- GSK3B_HUMAN
- GeneCards
- GSK3B
- Entrez Gene
- 2932
- GenAtlas
- GSK3B
- Internet
- Search Google