GenAge entry for PPP1CA (Homo sapiens)

Gene name (HAGRID: 227)

HGNC symbol
PPP1CA 
Aliases
PP1A; PP-1A; PP1alpha; PPP1A 
Common name
protein phosphatase 1, catalytic subunit, alpha isozyme 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

PPP1CA is part of protein phosphatase 1 (PP1), which is involved in different cellular processes including cell division, protein synthesis, and synaptic plasticity. It has also been associated with oncogene-induced senescence [3344]. PP1 inhibition in mice was associated with prolonged memory, and old mice had preserved memory, which suggests that PP1, including PPP1CA, could play a role in cognitive ageing [1407]. PPP1CA cardiac-specific overexpression in mice resulted in premature heart failure [1408]. Further research is necessary to establish whether PPP1CA is related to human ageing.

Cytogenetic information

Cytogenetic band
11q13
Location
67,398,181 bp to 67,401,905 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0005977; glycogen metabolic process
GO:0005979; regulation of glycogen biosynthetic process
GO:0005981; regulation of glycogen catabolic process
GO:0006470; protein dephosphorylation
GO:0007049; cell cycle
GO:0016311; dephosphorylation
GO:0030324; lung development
GO:0032091; negative regulation of protein binding
GO:0032922; circadian regulation of gene expression
GO:0036496; regulation of translational initiation by eIF2 alpha dephosphorylation
GO:0042752; regulation of circadian rhythm
And 7 more GO terms
Cellular component: GO:0000164; protein phosphatase type 1 complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005911; cell-cell junction
GO:0042587; glycogen granule
GO:0043197; dendritic spine
And 5 more GO terms
Function: GO:0004721; phosphoprotein phosphatase activity
GO:0004722; protein serine/threonine phosphatase activity
GO:0005515; protein binding
GO:0008157; protein phosphatase 1 binding
GO:0016791; phosphatase activity
GO:0032403; protein complex binding
GO:0043021; ribonucleoprotein complex binding
GO:0046872; metal ion binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ATM, HDAC3, AKT1, MYC, NCOR1, BRCA1, PTEN, BCL2, GSK3B, AR, RB1, GRB2, HDAC1, PTK2, CREB1, HSPA8, CDK1, MAX, MDM2, ESR1, DBN1, CSNK1E, ARNTL, CLOCK, SIRT7, C1QA, IKBKB
STRING interaction network
Protein-Protein network diagram for PPP1CA

Retrieve sequences for PPP1CA

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
gsp-2
Drosophila melanogaster
Pp1-87B
Drosophila melanogaster
Pp1-13C
Drosophila melanogaster
Pp1alpha-96A
Mus musculus
Ppp1ca
Rattus norvegicus
Ppp1ca
Saccharomyces cerevisiae
GLC7

Selected references

External links

EPD
HS_PPP1CA
ORF Accession
NM_002708
CDS Accession
NP_002699
OMIM
176875
HPRD
15942
Ensembl
PPP1CA
UniProt/Swiss-Prot
PP1A_HUMAN
GeneCards
PPP1CA
Entrez Gene
5499
UniGene
183994
GenAtlas
PPP1CA
Internet
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