GenAge entry for TBP (Homo sapiens)

Gene name (HAGRID: 194)

HGNC symbol
TBP 
Aliases
TFIID; GTF2D1; SCA17 
Common name
TATA box binding protein 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description

TBP is part of the TFIID general transcription factor. Because of its central role in the activation of eukaryotic genes, TBP is potentially involved in a large variety of processes. TBP-null mice die at embryonic stages [848]. Mutations in the human TBP gene have been associated with neurological diseases [846]. Although TBP has not been directly linked to human ageing, because it is involved in so many different processes, and potentially in neurodegenerative diseases, it is possible that TBP plays some role in human ageing.

Cytogenetic information

Cytogenetic band
6q27
Location
170,554,333 bp to 170,572,870 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006359; regulation of transcription from RNA polymerase III promoter
GO:0006361; transcription initiation from RNA polymerase I promoter
GO:0006362; transcription elongation from RNA polymerase I promoter
GO:0006363; termination of RNA polymerase I transcription
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006368; transcription elongation from RNA polymerase II promoter
GO:0006383; transcription from RNA polymerase III promoter
GO:0007283; spermatogenesis
GO:0016032; viral process
GO:0042795; snRNA transcription from RNA polymerase II promoter
And 4 more GO terms
Cellular component: GO:0000790; nuclear chromatin
GO:0001939; female pronucleus
GO:0001940; male pronucleus
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005669; transcription factor TFIID complex
GO:0005672; transcription factor TFIIA complex
GO:0005719; nuclear euchromatin
GO:0005737; cytoplasm
Function: GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001034; RNA polymerase III transcription factor activity, sequence-specific DNA binding
GO:0001103; RNA polymerase II repressing transcription factor binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0044212; transcription regulatory region DNA binding
GO:0070491; repressing transcription factor binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, E2F1, MYC, FOS, CREBBP, NR3C1, UBE2I, EP300, AR, RB1, HSF1, RELA, ERCC1, HDAC1, SP1, JUN, HMGB1, TAF1, TBP, SIN3A, MAX, MDM2, ESR1
STRING interaction network
Protein-Protein network diagram for TBP

Retrieve sequences for TBP

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
tbp-1
Danio rerio
tbp
Drosophila melanogaster
Tbp
Mus musculus
Tbp
Rattus norvegicus
Tbp
Saccharomyces cerevisiae
SPT15

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as tbp-1

Selected references

External links

EPD
ORF Accession
NM_003194
CDS Accession
NP_003185
OMIM
600075
HPRD
02511
Ensembl
TBP
UniProt/Swiss-Prot
TBP_HUMAN
GeneCards
TBP
Entrez Gene
6908
UniGene
590872
GenAtlas
TBP
Internet
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