GenAge entry for MAP3K5 (Homo sapiens)
Gene name (HAGRID: 179)
- HGNC symbol
- MAP3K5
- Aliases
- MAPKKK5; ASK1; MEKK5
- Common name
- mitogen-activated protein kinase kinase kinase 5
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
- Description
MAP3K5, also called ASK1, is involved in stress response and apoptosis [999]. Disruption of MAP3K5 in mice attenuates left ventricular remodelling [1723]. It is possible that MAP3K5 is related to age-related changes in stress response witnessed in a number of animal models. MAP3K5 has not been directly linked to human ageing.
Cytogenetic information
- Cytogenetic band
- 6q22.33
- Location
- 136,557,049 bp to 136,792,518 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000165; MAPK cascade
GO:0000186; activation of MAPKK activity
GO:0002931; response to ischemia
GO:0006468; protein phosphorylation
GO:0007254; JNK cascade
GO:0007257; activation of JUN kinase activity
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010666; positive regulation of cardiac muscle cell apoptotic process
GO:0016032; viral process
GO:0034976; response to endoplasmic reticulum stress
GO:0038066; p38MAPK cascade
And 18 more GO terms Cellular component: GO:0005829; cytosol
GO:0009897; external side of plasma membrane
GO:1902911; protein kinase complex
GO:1990604; IRE1-TRAF2-ASK1 complex
Function: GO:0000287; magnesium ion binding
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004709; MAP kinase kinase kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019901; protein kinase binding
GO:0019903; protein phosphatase binding
GO:0042803; protein homodimerization activity
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TXN, PTPN11, AKT1, CREBBP, HSP90AA1, EP300, FAS, APP, HSPA1A, YWHAZ, MAP3K5, PIK3R1, JAK2, STUB1, CDKN1A
- STRING interaction network
Retrieve sequences for MAP3K5
Homologs in model organisms
- Caenorhabditis elegans
- nsy-1
- Danio rerio
- map3k5
- Drosophila melanogaster
- Pk92B
- Mus musculus
- Map3k5
- Rattus norvegicus
- Map3k5
- Saccharomyces cerevisiae
- STE11
- Saccharomyces cerevisiae
- BCK1
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Caenorhabditis elegans is present as nsy-1
- CellAge
- This gene is present as MAP3K5
Selected references
External links
- EPD
- ORF Accession
- NM_005923
- CDS Accession
- NP_005914
- OMIM
- 602448
- HPRD
- 03904
- Ensembl
- MAP3K5
- UniProt/Swiss-Prot
- M3K5_HUMAN
- GeneCards
- MAP3K5
- Entrez Gene
- 4217
- GenAtlas
- MAP3K5
- Internet
- Search Google