GenAge entry for RB1 (Homo sapiens)

Gene name (HAGRID: 120)

HGNC symbol
RB1 
Aliases
RB; PPP1R130; OSRC 
Common name
retinoblastoma 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

RB1 is a tumour suppressor that acts as a transcriptional regulator to control cell cycle progression. Mice with disrupted RB1 are not viable [605]. Mutations in the human RB1 gene have been associated with cancer [991]. Clearly, RB1 plays a role in cellular senescence and oncogenesis [95], but it is unknown whether it influences human ageing.

Cytogenetic information

Cytogenetic band
13q14.2
Location
48,303,747 bp to 48,481,890 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000075; cell cycle checkpoint
GO:0000082; G1/S transition of mitotic cell cycle
GO:0000083; regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0001558; regulation of cell growth
GO:0001894; tissue homeostasis
GO:0006338; chromatin remodeling
GO:0006351; transcription, DNA-templated
GO:0006469; negative regulation of protein kinase activity
GO:0007050; cell cycle arrest
GO:0007070; negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle
GO:0007093; mitotic cell cycle checkpoint
And 37 more GO terms
Cellular component: GO:0000785; chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005819; spindle
GO:0008024; cyclin/CDK positive transcription elongation factor complex
GO:0016514; SWI/SNF complex
GO:0016605; PML body
GO:0035189; Rb-E2F complex
Function: GO:0001047; core promoter binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019900; kinase binding
GO:0031625; ubiquitin protein ligase binding
GO:0042802; identical protein binding
GO:0050681; androgen receptor binding
And 2 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, LMNA, STAT3, INS, MYC, FOS, HDAC3, BRCA1, HIF1A, ABL1, TOP2A, UBE2I, EP300, PML, AR, GRB2, FOXO3, FOXO1, FOXM1, SIRT1, HDAC1, MAPK8, MAPK14, SP1, JUN, HMGB1, CCNA2, FAS, TFAP2A, ATF2, TBP, HBP1, CDK1, TFDP1, E2F1, HDAC2, MDM2, TAF1, POLA1, TCF3, CEBPA, CEBPB, PPP1CA, CHEK2, PPARG, TP73, CDKN1A, TRAP1
STRING interaction network
Protein-Protein network diagram for RB1

Retrieve sequences for RB1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
lin-35
Danio rerio
rb1
Drosophila melanogaster
Rbf2
Drosophila melanogaster
Rbf
Mus musculus
Rb1
Rattus norvegicus
Rb1

In other databases

CellAge
  • This gene is present as RB1

Selected references

External links

EPD
ORF Accession
NM_000321
CDS Accession
NP_000312
OMIM
180200
HPRD
01574
Ensembl
RB1
UniProt/Swiss-Prot
RB_HUMAN
GeneCards
RB1
Entrez Gene
5925
UniGene
408528
GenAtlas
RB1
Internet
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