GenAge entry for ATP5O (Homo sapiens)

Gene name (HAGRID: 146)

HGNC symbol
ATP5O 
Aliases
OSCP; ATPO 
Common name
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description

ATP5O is a mitochondrial protein, part of the proton-transporting complex. It has been linked to ageing in lower organisms. In roundworms, lowering the activity of an ATP5O homologue during larval stages, but not during adulthood, extends lifespan [183]. Its involvement in mammalian ageing, however, is not known.

Cytogenetic information

Cytogenetic band
21q22.11
Location
33,903,453 bp to 33,915,854 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0006754; ATP biosynthetic process
GO:0015992; proton transport
GO:0042776; mitochondrial ATP synthesis coupled proton transport
Cellular component: GO:0005634; nucleus
GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0005753; mitochondrial proton-transporting ATP synthase complex
GO:0005886; plasma membrane
GO:0031012; extracellular matrix
GO:0070062; extracellular exosome
Function: GO:0005215; transporter activity
GO:0005515; protein binding
GO:0008144; drug binding
GO:0016887; ATPase activity
GO:0022857; transmembrane transporter activity
GO:0046933; proton-transporting ATP synthase activity, rotational mechanism
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
APP, ATF2
STRING interaction network
Protein-Protein network diagram for ATP5O

Retrieve sequences for ATP5O

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
atp-3
Danio rerio
atp5o
Drosophila melanogaster
Oscp
Mus musculus
Atp5o
Rattus norvegicus
Atp5o
Saccharomyces cerevisiae
ATP5
Schizosaccharomyces pombe
atp5

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as atp-3

Selected references

External links

EPD
HS_ATP5O
ORF Accession
NM_001697
CDS Accession
NP_001688
OMIM
600828
HPRD
02899
Ensembl
ATP5O
UniProt/Swiss-Prot
ATPO_HUMAN
GeneCards
ATP5O
Entrez Gene
539
GenAtlas
ATP5O
Internet
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