GenAge entry for PTK2B (Homo sapiens)

Gene name (HAGRID: 165)

HGNC symbol
PTK2B 
Aliases
CAKB; PYK2; RAFTK; PTK; CADTK; FAK2 
Common name
protein tyrosine kinase 2 beta 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

Involved in stress response and signal transduction, PTK2B is an important player in a variety of processes including the regulation of ion channels by calcium and MAPK signalling [769]. PTK2B is a focal adhesion kinase (FAK), which could be involved in cellular senescence and apoptosis [1716]. Its role, if any, in human ageing is unknown, but PTK2B could potentially be involved in downstream signalling cascades related to ageing.

Cytogenetic information

Cytogenetic band
8p21.1
Location
27,311,482 bp to 27,459,391 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000165; MAPK cascade
GO:0001525; angiogenesis
GO:0001556; oocyte maturation
GO:0001666; response to hypoxia
GO:0001954; positive regulation of cell-matrix adhesion
GO:0002040; sprouting angiogenesis
GO:0002250; adaptive immune response
GO:0002315; marginal zone B cell differentiation
GO:0006461; protein complex assembly
GO:0006468; protein phosphorylation
GO:0006915; apoptotic process
And 81 more GO terms
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005856; cytoskeleton
GO:0005925; focal adhesion
GO:0005938; cell cortex
GO:0014069; postsynaptic density
GO:0017146; NMDA selective glutamate receptor complex
GO:0030027; lamellipodium
GO:0030424; axon
And 9 more GO terms
Function: GO:0004683; calmodulin-dependent protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0004871; signal transducer activity
GO:0004972; NMDA glutamate receptor activity
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0032403; protein complex binding
GO:0043423; 3-phosphoinositide-dependent protein kinase binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
PTPN11, IL7R, EGFR, ERBB2, PRKCD, PTEN, HSP90AA1, GRB2, PTK2B, MAPT, JAK2, SOCS2
STRING interaction network
Protein-Protein network diagram for PTK2B

Retrieve sequences for PTK2B

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
kin-32
Danio rerio
ptk2ba
Danio rerio
ptk2bb
Mus musculus
Ptk2b
Rattus norvegicus
Ptk2b

Selected references

External links

EPD
ORF Accession
NM_173174
CDS Accession
NP_775266
OMIM
601212
HPRD
03131
Ensembl
PTK2B
UniProt/Swiss-Prot
FAK2_HUMAN
GeneCards
PTK2B
Entrez Gene
2185
UniGene
491322
GenAtlas
PTK2B
Internet
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