GenAge entry for AGTR1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 264)

HGNC symbol
AGTR1 
Aliases
AT1; AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B 
Common name
angiotensin II receptor, type 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

AGTR1 is a gene encoding for one of the Ang II type 1 receptors. Ang II is the central product of the renin-angiotensin system and plays a role in cardiac and renal pathologies. Disruption of AGTR1 in mice resulted in a significant prolongation of maximal lifespan compared to controls. The mice also developed less cardiac and vascular injury, and multiple organs from these mice displayed less oxidative damage [2148]. AGTR1 is involved in atherosclerosis [2151] and renal diseases [2152].

Cytogenetic information

Cytogenetic band
3q24
Location
148,697,871 bp to 148,743,003 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001558; regulation of cell growth
GO:0001822; kidney development
GO:0002018; renin-angiotensin regulation of aldosterone production
GO:0002034; regulation of blood vessel diameter by renin-angiotensin
GO:0003081; regulation of systemic arterial blood pressure by renin-angiotensin
GO:0007186; G-protein coupled receptor signaling pathway
GO:0007200; phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204; positive regulation of cytosolic calcium ion concentration
GO:0007266; Rho protein signal transduction
GO:0010744; positive regulation of macrophage derived foam cell differentiation
GO:0010873; positive regulation of cholesterol esterification
And 17 more GO terms
Cellular component: GO:0005622; intracellular
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0016021; integral component of membrane
Function: GO:0001596; angiotensin type I receptor activity
GO:0004945; angiotensin type II receptor activity
GO:0005515; protein binding
GO:0031711; bradykinin receptor binding
GO:0046982; protein heterodimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
JAK2
STRING interaction network
Protein-Protein network diagram for AGTR1

Retrieve sequences for AGTR1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
agtr1a
Danio rerio
agtr1b
Mus musculus
Agtr1b
Mus musculus
Agtr1a
Rattus norvegicus
Agtr1a
Rattus norvegicus
Agtr1b

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Agtr1a
LongevityMap
  • This gene is present as AGTR1

Selected references

External links

EPD
ORF Accession
NM_000685
CDS Accession
NP_000676
OMIM
106165
HPRD
00107
Ensembl
AGTR1
UniProt/Swiss-Prot
AGTR1_HUMAN
GeneCards
AGTR1
Entrez Gene
185
UniGene
477887
GenAtlas
AGTR1
Internet
Search Google