GenAge entry for E2F1 (Homo sapiens)

Gene name (HAGRID: 18)

HGNC symbol
E2F1 
Aliases
RBP3; RBBP3 
Common name
E2F transcription factor 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description

An important regulator of the cell cycle, E2F1 may mediate apoptosis in conjunction with TP53 [85]. Clearly, E2F1 appears to be related to cancer [86]. Its role in ageing, however, is unknown.

Cytogenetic information

Cytogenetic band
20q11.2
Location
33,675,486 bp to 33,686,404 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000077; DNA damage checkpoint
GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007283; spermatogenesis
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010628; positive regulation of gene expression
GO:0030900; forebrain development
GO:0043276; anoikis
GO:0043392; negative regulation of DNA binding
And 17 more GO terms
Cellular component: GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005739; mitochondrion
GO:0035189; Rb-E2F complex
Function: GO:0001047; core promoter binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019901; protein kinase binding
GO:0043565; sequence-specific DNA binding
GO:0046983; protein dimerization activity
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
ATM, IGF1, PARP1, BRCA1, CREBBP, NFKB1, EP300, GSK3B, ERCC3, AR, RB1, SIRT1, HDAC1, SP1, CCNA2, TBP, CDK1, TFDP1, MDM2, ESR1, CDKN2A, ATR, TP53BP1, NCOR2, CDKN1A, CDK7
STRING interaction network
Protein-Protein network diagram for E2F1

Retrieve sequences for E2F1

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
efl-2
Danio rerio
E2F1
Drosophila melanogaster
E2f1
Mus musculus
E2f1
Rattus norvegicus
E2f1
Rattus norvegicus
E2f1

In other databases

CellAge
  • This gene is present as E2F1

Selected references

External links

EPD
ORF Accession
NM_005225
CDS Accession
NP_005216
OMIM
189971
HPRD
01806
Ensembl
E2F1
UniProt/Swiss-Prot
E2F1_HUMAN
GeneCards
E2F1
Entrez Gene
1869
UniGene
654393
GenAtlas
E2F1
Internet
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