GenAge entry for CEBPB (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 89)

HGNC symbol
CEBPB 
Aliases
LAP; CRP2; NFIL6; IL6DBP; C/EBP-beta; TCF5 
Common name
CCAAT/enhancer binding protein (C/EBP), beta 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

Like CEBPA, CEBPB is a transcription factor involved in fat metabolism. CEBPB also appears to play a role in liver regeneration [1130]. Albeit it was not clear their ageing process was retarded, mice carrying the CEBPB gene instead of CEBPA lived 20% more than controls, burned more fat, and their mitochondria were more active [1122]. As such, it is possible that CEBPB plays a role in human ageing, though further studies are necessary to confirm this hypothesis.

Cytogenetic information

Cytogenetic band
20q13.1
Location
50,190,583 bp to 50,192,691 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001541; ovarian follicle development
GO:0001892; embryonic placenta development
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0006953; acute-phase response
GO:0006954; inflammatory response
GO:0006955; immune response
GO:0007613; memory
GO:0030182; neuron differentiation
GO:0032753; positive regulation of interleukin-4 production
GO:0033598; mammary gland epithelial cell proliferation
And 22 more GO terms
Cellular component: GO:0000779; condensed chromosome, centromeric region
GO:0000790; nuclear chromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0016363; nuclear matrix
GO:0036488; CHOP-C/EBP complex
Function: GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019900; kinase binding
And 7 more GO terms
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
STAT3, MYC, EGFR, NCOR1, BRCA1, CREBBP, NR3C1, EGR1, NFKB1, CEBPA, CEBPB, EP300, GSK3B, AR, RB1, FOXO1, HSF1, RELA, HDAC1, SP1, JUN, CREB1, ATF2, DDIT3, ESR1, TP63, PPARG, NCOR2
STRING interaction network
Protein-Protein network diagram for CEBPB

Retrieve sequences for CEBPB

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
cebp-2
Danio rerio
cebpb
Mus musculus
Cebpb
Rattus norvegicus
Cebpb

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Cebpb
CellAge
  • This gene is present as CEBPB

Selected references

External links

EPD
ORF Accession
NM_005194
CDS Accession
NP_005185
OMIM
189965
HPRD
01801
Ensembl
CEBPB
UniProt/Swiss-Prot
CEBPB_HUMAN
GeneCards
CEBPB
Entrez Gene
1051
UniGene
517106
GenAtlas
CEBPB
Internet
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