GenAge entry for EGR1 (Homo sapiens)
Gene name (HAGRID: 76)
- HGNC symbol
- EGR1
- Aliases
- TIS8; G0S30; NGFI-A; KROX-24; ZIF-268; AT225; ZNF225
- Common name
- early growth response 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
An important regulator of the cell cycle, EGR1 has been suggested to act upstream of ageing-related genes such as TP53 [163]. It also appears to be pro-apoptotic [466]. EGR1's role in ageing is unknown, but it might be part of its signalling cascade. Further studies are necessary to establish whether EGR1 is a factor in human ageing.
Cytogenetic information
- Cytogenetic band
- 5q31.1
- Location
- 138,465,492 bp to 138,469,315 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001666; response to hypoxia
GO:0002931; response to ischemia
GO:0006366; transcription from RNA polymerase II promoter
GO:0009749; response to glucose
GO:0030217; T cell differentiation
GO:0030509; BMP signaling pathway
GO:0032868; response to insulin
GO:0033233; regulation of protein sumoylation
GO:0035914; skeletal muscle cell differentiation
GO:0042981; regulation of apoptotic process
And 18 more GO terms Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
Function: GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000977; RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0010385; double-stranded methylated DNA binding
GO:0035035; histone acetyltransferase binding
GO:0043565; sequence-specific DNA binding
GO:0044729; hemi-methylated DNA-binding
And 2 more GO terms
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TP53, JUND, PTEN, CREBBP, CEBPB, EP300, RELA, SP1, MDM2, CTNNB1, CDKN2A
- STRING interaction network
Retrieve sequences for EGR1
Homologs in model organisms
- Caenorhabditis elegans
- egrh-1
- Caenorhabditis elegans
- egrh-2
- Danio rerio
- egr1
- Drosophila melanogaster
- sr
- Mus musculus
- Egr1
- Rattus norvegicus
- Egr1
- Saccharomyces cerevisiae
- MIG3
- Saccharomyces cerevisiae
- MIG1
- Saccharomyces cerevisiae
- MIG2
- Schizosaccharomyces pombe
- prz1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as MIG1
- GenAge microarray genes
- This gene is present as EGR1
- CellAge gene expression
- This gene is present as EGR1
Selected references
External links
- EPD
- ORF Accession
- NM_001964
- CDS Accession
- NP_001955
- OMIM
- 128990
- HPRD
- 00549
- Ensembl
- EGR1
- UniProt/Swiss-Prot
- EGR1_HUMAN
- GeneCards
- EGR1
- Entrez Gene
- 1958
- GenAtlas
- EGR1
- Internet
- Search Google